(S)-(-)-甲基丁二酸合成路线 （共 34 条）
反应条件
formic acid; dihydrogen peroxide; iodine; sodium carbonate; ozone; potassium iodide 1.) ethyl chloride, -70 deg C, 10 min; Multistep reaction;
参考文献
Journal of the American Chemical Society, , vol. 102, # 10 p. 3614 - 3618
反应条件
formic acid; (bppm)Rh(1,1,1,5,5,5,-hexafluoroacetylacetonate); triethylamine in dimethylsulfoxide-d6 T=30°C; 0.166667 h; Title compound not separated from byproducts.;
参考文献
Dalton Transactions, , # 5 p. 752 - 758
反应条件
1: 89 percent / LiOH, H2O / tetrahydrofuran / 1.) 0 deg C, 5 h, 2.) r.t., 2 h 2: 100 percent / TFA / 1.5 h / Ambient temperature View Scheme
参考文献
Journal of the Chemical Society - Perkin Transactions 1, , # 17 p. 2635 - 2643
反应条件
ruthenium trichloride; sodium periodate in tetrachloromethane; water; acetonitrile 3.5 h; Ambient temperature;
参考文献
Gramatica, P.; Manitto, P.; Monti, D.; Speranza, G.
Tetrahedron, 1988 , vol. 44, # 4 p. 1299 - 1304
反应条件
1.1: 108 mg / m-chloroperbenzoic acid; CF3CO2H / CH2Cl2 / 48 h 2.1: aq. H2O2; LiOH / tetrahydrofuran / 2 h / 0 °C 2.2: 17.3 mg / KOH / methanol / 8 h / 20 °C View Scheme
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 52, # 1 p. 95 - 103
反应条件
1.1: 200 mg / aq. NaIO4; OsO4 / tetrahydrofuran; diethyl ether / 48 h / 20 °C 2.1: 108 mg / m-chloroperbenzoic acid; CF3CO2H / CH2Cl2 / 48 h 3.1: aq. H2O2; LiOH / tetrahydrofuran / 2 h / 0 °C 3.2: 17.3 mg / KOH / methanol / 8 h / 20 °C View Scheme
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 52, # 1 p. 95 - 103
反应条件
hydrogen; lt;Rhlt;(2S,3S)-2,3-o-bis(diphenylphosphino)-N-phenyltartimidegt;Clgt;2 P=41800 Torr; 17 h; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Journal of Organometallic Chemistry, , vol. 229, # 1 p. 77 - 84
反应条件
hydrogenchloride in acetic acid 10 h; Heating;
参考文献
Bulletin of the Chemical Society of Japan, , vol. 54, # 7 p. 2107 - 2112
反应条件
zinc in acetic acid 4 h;
参考文献
Hirai, Nobuhiro; Okamoto, Masahiko; Udagawa, Hiroake; Yamamuro, Munehiro; Kato, Masayoshi; Koshimizu, Koichi
Bioscience, Biotechnology, and Biochemistry, 1994 , vol. 58, # 9 p. 1679 - 1684
反应条件
1: 1.) NaOH, 2.) 18-crown-6 / 1.) MeOH, 2.) EtOH, reflux, 2 h 2: 10 mg / Zn / acetic acid / 4 h View Scheme
参考文献
Bioscience, Biotechnology, and Biochemistry, , vol. 58, # 9 p. 1679 - 1684
