(S)-(-)-甲基丁二酸合成路线 （共 34 条）
反应条件
1: 1.) hydrogen bromide, 2.) hydrogen, Et3N / 2.) 5percent Pd/C / 1.) room temperature, 3 h, 2.) EtOAc, room temperature View Scheme
参考文献
Acta Chemica Scandinavica, Series B: Organic Chemistry and Biochemistry, , vol. 41, # 1 p. 13 - 17
反应条件
jones reagent; ozone 1.) acetone, -78 deg C; 2.) -> 0 deg C during 1 h; Yield given. Multistep reaction;
参考文献
Tetrahedron, , vol. 44, # 4 p. 1299 - 1304
参考文献
Justus Liebigs Annalen der Chemie, , vol. 365, p. 14 Anm.
反应条件
1: hydrochloric acid / 25 °C 2: water View Scheme
参考文献
Justus Liebigs Annalen der Chemie, , vol. 365, p. 14 Anm.
反应条件
Acidic aq. solution;
参考文献
Organic and Biomolecular Chemistry, , vol. 7, # 3 p. 435 - 438
反应条件
Yield given. Multistep reaction;
参考文献
Acta Chemica Scandinavica, Series B: Organic Chemistry and Biochemistry, , vol. 41, # 1 p. 13 - 17
参考文献
Journal of the Chemical Society, , p. 139,140
Journal of the Chemical Society, , p. 665
反应条件
1: acetyl chloride / 60 °C 2: N,N'-carbonyldiimidazole / CH2Cl2 / 0 - 45 °C View Scheme
参考文献
Pohlmann, Jens; Lampe, Thomas; Shimada, Mitsuyuki; Nell, Peter G.; Pernerstorfer, Josef; Svenstrup, Niels; Brunner, Nina A.; Schiffer, Guido; Freiberg, Christoph
Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 4 p. 1189 - 1192
反应条件
sodium hydroxide; acetic acid in methanol; ethylene glycol dimethyl ether; diethyl ether 2 h;
参考文献
Gramatica, P.; Manitto, P.; Monti, D.; Speranza, G.
Tetrahedron, 1988 , vol. 44, # 4 p. 1299 - 1304
参考文献
Fukuzawa, Shin-Ichi; Oki, Hiroshi; Hosaka, Mitsuteru; Sugasawa, Jun; Kikuchi, Satoshi
Organic Letters, 2007 , vol. 9, # 26 p. 5557 - 5560
