1-氯-2-脱氧-3,5-二-O-对氯苯甲酰基-D-核糖合成路线 （共 12 条）
反应条件
hydrogenchloride; acetic acid; acetyl chloride in 1,4-dioxane; chloroform T=13 - 15°C; Inert atmosphere;
参考文献
Albemarle Corporation
Patent: US2010/249394 A1, 2010 ;
Location in patent: Page/Page column 4-5 ;
反应条件
1: With triethylamine; 4-(N,N-dimethlyamino)pyridine in 1,4-dioxane T=15 - 18°C; 2: With hydrogenchloride; acetic acid; acetyl chloride in 1,4-dioxane T=12 - 18°C;
参考文献
US2010/249394 A1, ;
Page/Page column 4 ;
反应条件
1: 2-deoxy-D-ribofuranose With methanol; acetyl chloride T=25°C; 0.75 h; 2: 4-chloro-benzoyl chloride With pyridine; 4-(N,N-dimethlyamino)pyridine T=0 - 25°C; 3: With hydrogenchloride in diethyl ether; acetic acid T=0°C; 0.166667 h;
参考文献
Wang; Duan; Wiebe; Balzarini; De Clercq; Knaus
Nucleosides, Nucleotides and Nucleic Acids, 2001 , vol. 20, # 1-2 p. 11 - 40
反应条件
1: 96 percent / p-nitrophenol / CHCl3 / 12 h / 30 °C 2: ammonia / methanol / 16 h / 30 °C View Scheme
参考文献
Aoyama
Bulletin of the Chemical Society of Japan, 1987 , vol. 60, # 6 p. 2073 - 2077
反应条件
1: phosphate 2: 72 percent / purine nucleoside phosphorylase View Scheme
参考文献
Komatsu; Awano; Tanikawa; Itou; Ikeda
Nucleosides, Nucleotides and Nucleic Acids, 2001 , vol. 20, # 4-7 p. 1291 - 1293
反应条件
1: phosphate 2: 82 percent / purine nucleoside phosphorylase View Scheme
参考文献
Nucleosides, Nucleotides and Nucleic Acids, , vol. 20, # 4-7 p. 1291 - 1293
反应条件
1: 5-aza-cytosine With ammonium sulfate; 1,1,1,3,3,3-hexamethyl-disilazane Heating / reflux; 2: 3,5-di-O-(p-chlorobenzoyl)-2-deoxy-α-D-erythro-pentofuranosyl chloride With lithium trifluoromethane sulfonate in dichloromethane T=20 - 25°C; 4 h; 3: With ammonia; water; sodium hydrogencarbonate more than 3 stages;
参考文献
Cilag AG
Patent: EP2048151 A1, 2009 ;
Location in patent: Page/Page column 3 ;
反应条件
1: With lithium trifluoromethane sulfonate in dichloromethane T=20 - 25°C; 4 h; 2: With water; sodium hydrogencarbonate in cyclohexane; ethyl acetate; acetonitrile T=0 - 30°C; 3 h;
参考文献
EP2050757 A1, ;
Page/Page column 3-4 ;
反应条件
1: With trimethylsilyl trifluoromethanesulfonate in chloroform T=1°C; 21 h; Inert atmosphere; 2: With sodium hydrogencarbonate in chloroform; water pH=6;
参考文献
US2010/249394 A1, ;
Page/Page column 5 ;
反应条件
1: 21.1 percent / p-nitrophenol, pyridine / CHCl3 / 12 h / 30 °C 2: ammonia / methanol / 16 h / 30 °C View Scheme
参考文献
Aoyama
Bulletin of the Chemical Society of Japan, 1987 , vol. 60, # 6 p. 2073 - 2077
