(5-苯基-2-四唑)-乙酸合成路线 （共 5 条）
反应条件
sodium hydroxide 4 h; Heating;
参考文献
Maxwell, James R.; Wasdahl, Dan A.; Wolfson, Alan C.; Stenberg, Virgil I.
Journal of Medicinal Chemistry, 1984 , vol. 27, # 12 p. 1565 - 1570
反应条件
sodium hydroxide 3 h; Heating;
参考文献
Esikov; Zubarev; Bezklubnaya; Malin; Ostrovskii
Chemistry of Heterocyclic Compounds, 2002 , vol. 38, # 8 p. 986 - 991
反应条件
1: 89 percent / NaN3, NH4Cl / dimethylformamide / 17 h / Heating 2: 1.) EtONa / 1.) EtOH, reflux, 2.) EtOH, reflux, 16 h 3: 75 percent / aq. NaOH / 4 h / Heating View Scheme
参考文献
Maxwell, James R.; Wasdahl, Dan A.; Wolfson, Alan C.; Stenberg, Virgil I.
Journal of Medicinal Chemistry, 1984 , vol. 27, # 12 p. 1565 - 1570
反应条件
1: 68 percent / Et3N / acetonitrile / 24 h / 20 °C 2: 93 percent / aq. NaOH / 3 h / Heating View Scheme
参考文献
Maxwell, James R.; Wasdahl, Dan A.; Wolfson, Alan C.; Stenberg, Virgil I.
Journal of Medicinal Chemistry, 1984 , vol. 27, # 12 p. 1565 - 1570
反应条件
1: 96 percent / phosphorus pentachloride / 100 °C
2: hydrazine hydrate / tetrahydrofuran
View Scheme
参考文献
Putis; Zubarev; Poplavskii; Ostrovskii
Chemistry of Heterocyclic Compounds, 2004 , vol. 40, # 7 p. 854 - 861
