1-(甲基磺酰基)-4-哌啶羧酸乙酯合成路线 （共 7 条）
反应条件
triethylamine in dichloromethane T=0 - 10°C;
参考文献
AstraZeneca AB
Patent: US2008/139613 A1, 2008 ;
Location in patent: Page/Page column 7 ;
US 20080139613 A1
反应条件
1: 92 percent / NaOH / H2O / 3 h 2: 97 percent / oxalyl chloride; DMF / CH2Cl2 / 3 h / 20 °C View Scheme
参考文献
Imamura, Shinichi; Nishikawa, Youichi; Ichikawa, Takashi; Hattori, Taeko; Matsushita, Yoshihiro; Hashiguchi, Shohei; Kanzaki, Naoyuki; Iizawa, Yuji; Baba, Masanori; Sugihara, Yoshihiro
Bioorganic and Medicinal Chemistry, 2005 , vol. 13, # 2 p. 397 - 416
反应条件
1: With diisobutylaluminium hydride in tetrahydrofuran; dichloromethane T=-77 - -75°C; 3 h; 2: With water; ammonium chloride in tetrahydrofuran; dichloromethane T=-67°C; 0.5 h; Product distribution / selectivity;
参考文献
AstraZeneca AB
Patent: US2008/139613 A1, 2008 ;
Location in patent: Page/Page column 8 ;
US 20080139613 A1
反应条件
1: With sodium hydroxide; water T=20°C; 3 h; 2: With hydrogenchloride T=0°C; 1 h;
参考文献
Takeda Chemical Industries, Ltd.
Patent: EP1359145 A1, 2003 ;
Location in patent: Page/Page column 31 ;
反应条件
in tetrahydrofuran; methanol; diethyl ether; toluene
参考文献
Takeda Chemical Industries, Ltd.
Patent: US6562978 B1, 2003 ;
反应条件
1: With lithium aluminium tetrahydride in tetrahydrofuran
T=0 - 20°C;
2: With water in tetrahydrofuran
T=0 - 10°C;
3: With hydrogenchloride in tetrahydrofuran; water
T=0 - 20°C; pH=< 2; 0.25 h;
参考文献
AstraZeneca AB
Patent: US2008/139613 A1, 2008 ;
Location in patent: Page/Page column 7 ;
US 20080139613 A1
反应条件
1: lithium aluminum hydride / tetrahydrofuran / 0 °C
2: pyridinium chlorochromate; Celite / CH2Cl2 / 20 °C
3: tetrahydrofuran / -78 °C
4: pyridinium chlorochromate; Celite / CH2Cl2 / 20 °C
View Scheme
参考文献
Chang, Meng-Yang; Kung, Yung-Hua; Ma, Chih-Chong
Tetrahedron Letters, 2007 , vol. 48, # 2 p. 199 - 202
