6-硝基-2H-苯并[b][1,4]噻嗪-3(4H)-酮合成路线 （共 9 条）
反应条件
triethylamine in N,N-dimethyl-formamide T=180°C; 0.25 h; microwave irradiation;
参考文献
AMGEN INC.
Patent: WO2007/48070 A2, 2007 ;
Location in patent: Page/Page column 107 ;
反应条件
sodium hydride in N,N-dimethyl-formamide T=0 - 20°C; 2 h;
参考文献
ACTELION PHARMACEUTICALS LTD.
Patent: US2009/105232 A1, 2009 ;
Location in patent: Page/Page column 31 ;
US 20090105232 A1
反应条件
sodium hydroxide in water 1.5 h; Heating / reflux;
参考文献
Schering Corporation and Pharmacopeia Drug Discovery, Inc.
Patent: US2007/93477 A1, 2007 ;
Location in patent: Page/Page column 34 ;
反应条件
sodium hydroxide in ethanol Reflux;
参考文献
AMGEN INC.; BROWN, Matthew; CHEN, Yi; CUSHING, Timothy D.; GONZALEZ LOPEZ DE TURISO, Felix; HE, Xiao; KOHN, Todd J.; LOHMAN, Julia Winslow; PATTAROPONG, Vatee; SEGANISH, Jennifer; SHIN, Youngsook; SIMARD, Jillian L.
Patent: WO2010/151737 A2, 2010 ;
Location in patent: Page/Page column 144-145 ;
WO 2010/151737 A2
反应条件
1: Na2S*9H2O / ethanol / 0.5 h / Heating 2: aq. NaOH / 0.5 h / Heating View Scheme
参考文献
Brandao; Guarda; Pitta; Chantegrel; Perrissin; Souza; Galdino; Thomasson; Lima; Leite; Luu-Duc
Bollettino Chimico Farmaceutico, 2000 , vol. 139, # 2 p. 54 - 58
反应条件
sodium hydrogencarbonate in ethanol; water
参考文献
Chandramohan,M.R. et al.
Indian Journal of Chemistry, 1969 , vol. 7, p. 1006 - 1009
参考文献
Goudie,R.S.; Preston,P.N.
Journal of the Chemical Society [Section] C: Organic, 1971 , p. 1718 - 1721
反应条件
sodium hydroxide Addition; cyclization; 0.5 h; Heating;
参考文献
Brandao; Guarda; Pitta; Chantegrel; Perrissin; Souza; Galdino; Thomasson; Lima; Leite; Luu-Duc
Bollettino Chimico Farmaceutico, 2000 , vol. 139, # 2 p. 54 - 58
反应条件
iron; acetic acid T=60°C; 1 h;
参考文献
AMGEN INC.
Patent: WO2007/48070 A2, 2007 ;
Location in patent: Page/Page column 107-108 ;
