6-氨基-2H-1,4-苯并噻嗪-3(4H)-酮合成路线 （共 6 条）
反应条件
iron; acetic acid in water; ethyl acetate T=20 - 80°C;
参考文献
Lanter, James C.; Sui, Zhihua; Fiordeliso, James J.
Patent: US2004/14743 A1, 2004 ;
Location in patent: Page/Page column 14 ;
US 20040014743 A1
反应条件
1: With sodium hydride in N,N-dimethyl-formamide T=0 - 20°C; 2 h; 2: With iron; acetic acid T=60°C; 1 h;
参考文献
ACTELION PHARMACEUTICALS LTD
Patent: WO2007/107965 A1, 2007 ;
Location in patent: Page/Page column 78 ;
反应条件
iron; acetic acid T=60°C; 1 h;
参考文献
AMGEN INC.
Patent: WO2007/48070 A2, 2007 ;
Location in patent: Page/Page column 107-108 ;
参考文献
Vertex Pharmaceuticals Incorported
Patent: US2011/98311 A1, 2011 ;
反应条件
hydrogenchloride; tin; tin(ll) chloride
参考文献
Mackie; Raeburn
Journal of the Chemical Society, 1952 , p. 787,788
反应条件
1: 6-amino-2H-1,4-benzthiazin-3(4H)-one With sodium hydride in DMF (N,N-dimethyl-formamide) T=20°C; 0.5 h; 2: methyl iodide in DMF (N,N-dimethyl-formamide) T=0°C; 0.5 h;
参考文献
Cai, Jianping; Dimoudis, Nikolaos; Honold, Konrad; Luk, Kin-Chun; Scheiblich, Stefan; Sudergat, Hilke; Tiefenthaler, Georg; Tonn, Oliver
Patent: US2004/87600 A1, 2004 ;
Location in patent: Page 17 ;
