(1-溴-3-氯丙基)苯合成路线 （共 11 条）
反应条件
phosphorus tribromide in diethyl ether T=20°C; 2 h; Inert atmosphere;
参考文献
WO2012/13691 A1, ;
Page/Page column 30-31 ;
反应条件
N-bromosuccinmide; dibenzoyl peroxide in tetrachloromethane
反应条件
N-bromosuccinmide in tetrachloromethane
反应条件
1: aq. NaBH4 / tetrahydrofuran / 2 h / 20 °C 2: PBr3 / diethyl ether / 2 h / 20 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 47, # 16 p. 3924 - 3926
参考文献
Eli Lilly and Company
Patent: US4313896 A1, 1982 ;
反应条件
1: 4-(trifluoromethyl)phenol With sodium hydride in N,N-dimethyl-formamide
T=20°C; 0.5 h;
2: 1-bromo-3-chloro-1-phenylpropane in N,N-dimethyl-formamide
T=20°C; 60 h;
参考文献
Andersen, Jacob; Stuhr-Hansen, Nicolai; Zachariassen, Linda Gronborg; Koldso, Heidi; Schiott, Birgit; Stromgaard, Kristian; Kristensen, Anders S.
Molecular Pharmacology, 2014 , vol. 85, # 5 p. 703 - 714
反应条件
NaH in ethanol; N,N-dimethyl-formamide
参考文献
Eli Lilly and Company
Patent: US4313896 A1, 1982 ;
反应条件
in ethanol; N,N-dimethyl-formamide; mineral oil
参考文献
Eli Lilly and Company
Patent: US4313896 A1, 1982 ;
反应条件
1: 2-methoxy-phenol With sodium hydride in N,N-dimethyl-formamide; mineral oil
T=20°C; 0.5 h; Inert atmosphereSonication;
2: 1-bromo-3-chloro-1-phenylpropane in N,N-dimethyl-formamide; mineral oil
T=20°C; 12 h; Inert atmosphere;
参考文献
Andersen, Jacob; Stuhr-Hansen, Nicolai; Zachariassen, Linda Gronborg; Koldso, Heidi; Schiott, Birgit; Stromgaard, Kristian; Kristensen, Anders S.
Molecular Pharmacology, 2014 , vol. 85, # 5 p. 703 - 714
参考文献
Eli Lilly and Company
Patent: US4626549 A1, 1986 ;
Title/Abstract Full Text Show Details
Eli Lilly and Company
Patent: US4018895 A1, 1977 ;
