5-甲氧基-1H-吲哚-2-羧酸合成路线 （共 8 条）
反应条件
manganese(IV) oxide in dichloromethane T=35°C;
参考文献
Tsotinis, Andrew; Afroudakis, Pandelis A.; Davidson, Kathryn; Prashar, Anjali; Sugden, David
Journal of Medicinal Chemistry, 2007 , vol. 50, # 25 p. 6436 - 6440
反应条件
1: 89 percent / thionyl chloride / 4 h / Heating 2: 98 percent / LiAlH4 / diethyl ether; tetrahydrofuran / 1.5 h / Heating 3: 60 percent / CrO3, pyridine / CH2Cl2 / 19 h / Ambient temperature View Scheme
参考文献
Sumitomo Pharmaceuticals Company, Limited
Patent: EP1479384 A1, 2004 ;
反应条件
1: 98 percent / LiAlH4 / diethyl ether; tetrahydrofuran / 1.5 h / Heating 2: 60 percent / CrO3, pyridine / CH2Cl2 / 19 h / Ambient temperature View Scheme
参考文献
Meyer; Kruse
Journal of Organic Chemistry, 1984 , vol. 49, # 17 p. 3195 - 3199
反应条件
1: LiAlH4 / tetrahydrofuran / 0.75 h / Ambient temperature 2: MnO2 / CH2Cl2 / 7 h / Ambient temperature View Scheme
参考文献
Spadoni, Gilberto; Balsamini, Cesarino; Bedini, Annalida; Diamantini, Giuseppe; Di Giacomo, Barbara; Tontini, Andrea; Tarzia, Giorgio; Mor, Marco; Plazzi, Pier Vincenzo; Rivara, Silvia; Nonno, Romolo; Pannacci, Marilou; Lucini, Valeria; Fraschini, Franco; Stankov, Bojidar Michaylov
Journal of Medicinal Chemistry, 1998 , vol. 41, # 19 p. 3624 - 3634
反应条件
1: benzene / Heating 2: NaNH2, t-BuONa / tetrahydrofuran / 48 h / Ambient temperature 3: aq. HCl / acetone / 1 h / Ambient temperature View Scheme
参考文献
Kuehm-Caubere, Catherine; Rodriguez, Ivan; Pfeiffer, Bruno; Renard, Pierre; Caubere, Paul
Journal of the Chemical Society - Perkin Transactions 1, 1997 , # 19 p. 2857 - 2862
反应条件
1: tetrahydrofuran; diethyl ether / 0.83 h / 0 - 20 °C 2: MnO2 / CHCl3 / 0.67 h / Heating View Scheme
参考文献
Palmer, Brian D.; Thompson, Andrew M.; Booth, R. John; Dobrusin, Ellen M.; Kraker, Alan J.; Lee, Ho H.; Lunney, Elizabeth A.; Mitchell, Lorna H.; Ortwine, Daniel F.; Smaill, Jeff B.; Swan, Leesa M.; Denny, William A.
Journal of Medicinal Chemistry, 2006 , vol. 49, # 16 p. 4896 - 4911
反应条件
Rh(dppp)2Cl 18 h; Heating;
参考文献
Meyer; Kruse
Journal of Organic Chemistry, 1984 , vol. 49, # 17 p. 3195 - 3199
反应条件
1: tetrahydrofuran; diethyl ether / 0.83 h / 0 - 20 °C
2: 1.80 g / MnO2 / CHCl3 / 0.67 h / Heating
View Scheme
参考文献
Palmer, Brian D.; Thompson, Andrew M.; Booth, R. John; Dobrusin, Ellen M.; Kraker, Alan J.; Lee, Ho H.; Lunney, Elizabeth A.; Mitchell, Lorna H.; Ortwine, Daniel F.; Smaill, Jeff B.; Swan, Leesa M.; Denny, William A.
Journal of Medicinal Chemistry, 2006 , vol. 49, # 16 p. 4896 - 4911
