18-甲基-4-雌烯-3,17-二酮合成路线 （共 15 条）
反应条件
1.1: 90 percent / triethyl orthoformate; p-TsOH / CH2Cl2 / 3 h / 10 °C 2.1: t-BuOK / tetrahydrofuran / 0.17 h / 20 °C 2.2: tetrahydrofuran / 2 h / 20 °C 3.1: Et3N / xylene / 2.5 h / 140 °C 4.1: 94 percent / tetrahydrofuran / 2 h / 0 °C 5.1: 90 percent / aq. HCl / acetone / 0.75 h / 20 °C View Scheme
参考文献
Hofmeister; Annen; Laurent; Petzoldt; Wiechert
Arzneimittel-Forschung/Drug Research, 1986 , vol. 36, # 5 p. 781 - 783
反应条件
(i) liq. NH3 (ii) /BRN= 4147360/, benzene, Et2O; Multistep reaction;
参考文献
Rosenberger; Fraher; Saucy
Helvetica chimica acta, 1971 , vol. 54, # 8 p. 2857 - 2870
反应条件
mushroom Penicillium raistrickii (ATCC 10490) in water T=30°C; 70 h;
参考文献
Hofmeister; Annen; Laurent; Petzoldt; Wiechert
Arzneimittel-Forschung/Drug Research, 1986 , vol. 36, # 5 p. 781 - 783
→
3625-82-9(8R,9S,13S,14S,17S)-13-乙基-3-甲氧基-6,7,8,9,11,12,14,15,16,17-十氢环戊烯并[a]菲-17-醇
反应条件
2: 85 percent / 1 N aq. KOH / tetrahydrofuran; methanol / 1 h / Ambient temperature View Scheme
参考文献
Rao, Pemmaraju N.; Cessac, James W.; Kim, Hyun K.
Steroids, 1994 , vol. 59, # 11 p. 621 - 627
反应条件
Cylindrocarpon dydimum in water
Enzymatic reaction; Product distribution / selectivity;
参考文献
RICHTER GEDEON NYRT.
Patent: WO2008/32131 A1, 2008 ;
Location in patent: Page/Page column 12-14 ;
