2-甲基咪唑并[1,2-a]吡啶-3-羧酸合成路线 （共 8 条）
反应条件
1: in ethanol T=80°C; 48 h; 2: With water; sodium hydroxide in ethanol T=70°C; 1 h; 3: With hydrogenchloride in ethanol; water Cooling with ice;
参考文献
MILLENNIUM PHARMACEUTICALS, INC.; TAKEDA PHARMACEUTICAL COMPANY LIMITED; BANNO, Hiroshi; HIROSE, Masaaki; KURASAWA, Osamu; LANGSTON, Steven, P.; MIZUTANI, Hirotake; SHI, Zhan; VISIERS, Irache; VOS, Tricia, J.; VYSKOCIL, Stepan
Patent: WO2010/90716 A1, 2010 ;
Location in patent: Page/Page column 321 ;
反应条件
water; potassium hydroxide in methanol T=70°C; 5 h;
参考文献
Kuemmerle, Arthur E.; Schmitt, Martine; Cardozo, Suzana V. S.; Lugnier, Claire; Villa, Pascal; Lopes, Alexandra B.; Romeiro, Nelilma C.; Justiniano, Helene; Martins, Marco A.; Fraga, Carlos A. M.; Bourguignon, Jean-Jacques; Barreiro, Eliezer J.
Journal of Medicinal Chemistry, 2012 , vol. 55, # 17 p. 7525 - 7545
反应条件
1: CCl4; N-bromo-succinimide 2: aqueous KOH View Scheme
参考文献
Journal of the American Chemical Society, , vol. 76, p. 1845
参考文献
Journal of the American Chemical Society, , vol. 76, p. 1845
反应条件
1: acetonitrile / 80 °C 2: ethanol; sodium hydroxide View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 22, # 5 p. 1870 - 1873
反应条件
water; sodium hydroxide 3 h;
参考文献
Journal of Chemical Research, , vol. 35, # 4 p. 243 - 245
反应条件
1: With thionyl chloride in toluene T=100°C; 24 h; 2: With ammonia in tetrahydrofuran; water T=20°C; 3 h;
参考文献
MILLENNIUM PHARMACEUTICALS, INC.; TAKEDA PHARMACEUTICAL COMPANY LIMITED; BANNO, Hiroshi; HIROSE, Masaaki; KURASAWA, Osamu; LANGSTON, Steven, P.; MIZUTANI, Hirotake; SHI, Zhan; VISIERS, Irache; VOS, Tricia, J.; VYSKOCIL, Stepan
Patent: WO2010/90716 A1, 2010 ;
Location in patent: Page/Page column 321-322 ;
反应条件
1: thionyl chloride / 2 h / Reflux
2: triethylamine / dichloromethane / 0.5 h
View Scheme
参考文献
Han, Tao; Shi, Zhichuan; Peng, Yongle; Zhao, Zhigang
Journal of Chemical Research, 2011 , vol. 35, # 4 p. 243 - 245
