2,6-二甲基-4-(4-硝基苯基)-1,4-二氢吡啶-3,5-二羧酸二甲酯合成路线 （共 12 条）
反应条件
1: 25 percent / N-bromosuccinimide / CHCl3 / 1.) 1 h, 2.) reflux, 1 h 2: 80 percent / 3 N HNO3 / 2 h / 60 - 70 °C View Scheme
参考文献
Pharmaceutical Chemistry Journal, , vol. 23, # 2 p. 137 - 139
Khimiko-Farmatsevticheskii Zhurnal, , vol. 23, # 2 p. 176 - 178
反应条件
N-bromosuccinmide in chloroform 1.) 1 h, 2.) reflux, 1 h;
参考文献
Skrastin'sh, I. P.; Kastron, V. V.; Vitolin', R. O.; Stivrinya, M. I.; Zolotoyabko, R. M.; Dubur, G. Ya.
Pharmaceutical Chemistry Journal, 1989 , vol. 23, # 2 p. 137 - 139
Khimiko-Farmatsevticheskii Zhurnal, 1989 , vol. 23, # 2 p. 176 - 178
反应条件
ammonium acetate
T=90°C; Hantzsch pyridine synthesis; 0.333333 h;
参考文献
Koukabi, Nadiya; Kolvari, Eskandar; Khazaei, Ardeshir; Zolfigol, Mohammad Ali; Shirmardi-Shaghasemi, Behzad; Khavasi, Hamid Reza
Chemical Communications, 2011 , vol. 47, # 32 p. 9230 - 9232
反应条件
1: Hantzsch-type condensation; 0.0833333 h; Neat (no solvent)Reflux;
2: With ammonium acetate
Hantzsch-type condensation; Neat (no solvent)Reflux;
参考文献
Rostamnia, Sadegh; Lamei, Kamran
Chinese Chemical Letters, 2012 , vol. 23, # 8 p. 930 - 932
反应条件
Candida antarctica lipase B immobilized on acrylic resin in tert-butyl methyl ether
T=50°C; Hantzsch-type reaction; 72 h;
参考文献
Wang, Jun-Liang; Liu, Bo-Kai; Yin, Cui; Wu, Qi; Lin, Xian-Fu
Tetrahedron, 2011 , vol. 67, # 14 p. 2689 - 2692
反应条件
ammonium acetate in neat (no solvent)
T=60°C; Hantzsch Dihydropyridine Synthesis; 0.333333 h;
参考文献
Pramanik, Malay; Bhaumik, Asim
Journal of Materials Chemistry A, 2013 , vol. 1, # 37 p. 11210 - 11220
反应条件
p-toluenesulfonic acid sodium salt in water
Hantzsch Dihydropyridine Synthesis; 0.133333 h; Microwave irradiationRefluxGreen chemistry; Reagent/catalystTime;
参考文献
Khadilkar, Bhushan M.; Madyar, Virendra R.
Organic Process Research and Development, 2001 , vol. 5, # 4 p. 452 - 455
反应条件
ammonium hydroxide; acetic acid in ethanol
T=20°C; 18 h;
参考文献
O'Callaghan, Conor N.
Journal of Chemical Research, Miniprint, 1986 , # 9 p. 2901 - 2915
反应条件
in acetonitrile; trifluoroacetic acid
0.5 h; Ambient temperature;
参考文献
Singh, Harjit; Singh, Kamaljit
Tetrahedron, 1989 , vol. 45, # 12 p. 3967 - 3974
反应条件
1: methanol; 5-acetyl-2,2-dimethyl-[1,3]dioxane-4,6-dione Microwave irradiation;
2: 4-nitrobenzaldehdye With ammonium acetate in methanol
Microwave irradiation;
参考文献
More; Mahulikar
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2011 , vol. 50, # 5 p. 745 - 747
