1,3,5-三苯基-1H-吡唑合成路线 （共 78 条）
反应条件
1.1: acetic acid / ethanol / 4 h / |Reflux
2.1: sodium hydride / tetrahydrofuran / 0.25 h / 0 °C
2.2: 5 h / 20 °C / |Reflux
3.1: copper(I) bromide dimethylsulfide complex; 1,8-diazabicyclo[5.4.0]undec-7-ene; potassium iodide; caesium carbonate / 1,2-dichloro-ethane / 5 h / 135 °C / |Schlenk technique
View Scheme
参考文献
Zhang, Guangwu; Zhao, Yan; Ge, Haibo
Angewandte Chemie - International Edition, 2013 , vol. 52, # 9 p. 2559 - 2563
Angew. Chem., 2013 , vol. 125, # 9 p. 2619 - 2623,5
参考文献
Cromwell; Hoeksema
Journal of the American Chemical Society, 1948 , vol. 71, p. 716,718
反应条件
1: 5 wt Cu/Fe / N,N-dimethyl-formamide / 3 h / 100 °C
2: N,N-dimethyl-formamide / 5 h / 100 °C
View Scheme
参考文献
Kovacs, Szabolcs; Novak, Zoltan
Tetrahedron, 2013 , vol. 69, # 43 p. 8987 - 8993
反应条件
1: 5 wt Cu/Fe / N,N-dimethyl-formamide / 3 h / 100 °C
2: N,N-dimethyl-formamide / 5 h / 100 °C
View Scheme
参考文献
Kovacs, Szabolcs; Novak, Zoltan
Tetrahedron, 2013 , vol. 69, # 43 p. 8987 - 8993
反应条件
boron trifluoride diethyl etherate in chloroform
Heating;
参考文献
Baba, N.; Soufiaoui, M.
Tetrahedron Letters, 1990 , vol. 31, # 12 p. 1709 - 1712
反应条件
boron trifluoride diethyl etherate in chloroform
Heating;
参考文献
Baba, N.; Soufiaoui, M.
Tetrahedron Letters, 1990 , vol. 31, # 12 p. 1709 - 1712
反应条件
in methanol
5 h; Heating;
参考文献
Nakhmanovich A. S.; Glotova, T. E.
Chemistry of Heterocyclic Compounds (New York, NY, United States), 1985 , vol. 21, # 8 p. 955
Khimiya Geterotsiklicheskikh Soedinenii, 1985 , vol. 21, # 8 p. 1136 - 1137
反应条件
1: 89 percent / BF3*Et2O / 8 h / 20 °C
2: 89 percent / acetonitrile / 2 h / 20 °C
View Scheme
参考文献
Stefane, Bogdan; Polanc, Slovenko
New Journal of Chemistry, 2002 , vol. 26, # 1 p. 28 - 32
反应条件
1: 85 percent / Pd(OAc)2; DPPF
2: 88 percent / cc. HCl / ethanol / Heating
View Scheme
参考文献
Haddad, Nizar; Baron, James
Tetrahedron Letters, 2002 , vol. 43, # 12 p. 2171 - 2173
参考文献
Wislicenus,J.
Justus Liebigs Annalen der Chemie, 1899 , vol. 308, p. 255
