4-N-叔丁氧羰基氨基-3-氟苯硼酸合成路线 （共 4 条）
反应条件
1: With n-butyllithium in tetrahydrofuran T=-85°C; 1 h; 2: With boric acid trimethyl ester in tetrahydrofuran T=-90 - 20°C; 3: With water; acetic acid more than 3 stages;
参考文献
BAYER SCHERING PHARMA AKTIENGESELLSCHAFT
Patent: WO2007/147574 A1, 2007 ;
Location in patent: Page/Page column 55-56 ;
反应条件
1: tert-butyl N-(4-bromo-2-fluorophenyl)carbamate With n-butyllithium in tetrahydrofuran T=-85°C; 1 h; 2: boric acid trimethyl ester in tetrahydrofuran T=-90°C;
参考文献
Bayer Schering Pharma Aktiengesellschaft
Patent: EP1878726 A1, 2008 ;
Location in patent: Page/Page column 38 ;
EP 1878726 A1
反应条件
1: With pyridine; copper diacetate in tetrahydrofuran T=20°C; 16 h; 2: With hydrogenchloride in water; ethyl acetate T=20°C; 1 h;
参考文献
DuPont Pharmaceuticals Company
Patent: US6339099 B1, 2002 ;
Location in patent: Page column 119, 120 ;
反应条件
in methanol T=20°C; 1 h;
参考文献
WO2007/147574 A1, ;
Page/Page column 56 ;
