1: 95 percent / acetonitrile / 1.) reflux, 3 h, 2.) r.t., overnight 2: DCC, DMAP / CH2Cl2 / Ambient temperature 3: Et3N / dioxane / 12 h / Heating 4: 92 percent / KOH / ethanol / 2 h / Heating 5: 93 percent / imidazole / dimethylformamide / 24 h / Ambient temperature 7: Ph2PLi / tetrahydrofuran; hexane / 16 h / Heating 8: Bu4NF / tetrahydrofuran / Ambient temperature View Scheme

<b>With</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '1098214', constants.ctx, '0')">hydrogenchloride</a>;&nbsp;<a href="#" onclick="return RXDsubstances(event, this, '3587155', constants.ctx, '0')">water</a>;&nbsp;<a href="#" onclick="return RXDsubstances(event, this, '4152656', constants.ctx, '0')">sodium cyanoborohydride</a>;&nbsp;<a href="#" onclick="return RXDsubstances(event, this, '506007', constants.ctx, '0')">acetic acid</a>&nbsp;<b>in</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '102391', constants.ctx, '0')">tetrahydrofuran</a> <br />1&nbsp;h;&nbsp;&nbsp;Ambient temperature;&nbsp;<br /> &nbsp;

<b>Multi-step reaction with 2 steps<br /> </b>1: 84 percent / DCC, DMAP / CH₂Cl₂ / 24 h / Ambient temperature<br />2: 99 percent / NaBH₃CN, AcOH, HCl, H₂O / tetrahydrofuran / 1 h / Ambient temperature<br /> <br /> &nbsp;

<b>Multi-step reaction with 2 steps<br /> </b>1: 84 percent / DCC, DMAP / CH₂Cl₂ / 24 h / Ambient temperature<br />2: 99 percent / NaBH₃CN, AcOH, HCl, H₂O / tetrahydrofuran / 1 h / Ambient temperature<br /> <br /> &nbsp;