2-(4-羟基苯基)丙腈合成路线 （共 36 条）
反应条件
sodium nitrite in hydrogenchloride; water
参考文献
FGN, INC.; THE UNIVERSITY OF ARIZONA
Patent: EP485173 A2, 1992 ;
反应条件
1: aq. HBr; acetic acid / Heating 2: KBH4; KOH / methanol / Heating 3: dimethylformamide / 6 h / 130 °C View Scheme
参考文献
Yang, Zhong-Shun; Zhou, Wen-Liang; Sui, Yi; Wang, Jun-Xia; Wu, Jin-Ming; Zhou, Yu; Zhang, Yu; He, Pei-Lan; Han, Ji-Ye; Tang, Wei; Li, Ying; Zuo, Jian-Ping
Journal of Medicinal Chemistry, 2005 , vol. 48, # 14 p. 4608 - 4617
反应条件
1: KBH4; KOH / methanol / Heating 2: dimethylformamide / 6 h / 130 °C View Scheme
参考文献
Yang, Zhong-Shun; Zhou, Wen-Liang; Sui, Yi; Wang, Jun-Xia; Wu, Jin-Ming; Zhou, Yu; Zhang, Yu; He, Pei-Lan; Han, Ji-Ye; Tang, Wei; Li, Ying; Zuo, Jian-Ping
Journal of Medicinal Chemistry, 2005 , vol. 48, # 14 p. 4608 - 4617
反应条件
in N,N-dimethyl-formamide T=130°C; 6 h;
参考文献
Yang, Zhong-Shun; Zhou, Wen-Liang; Sui, Yi; Wang, Jun-Xia; Wu, Jin-Ming; Zhou, Yu; Zhang, Yu; He, Pei-Lan; Han, Ji-Ye; Tang, Wei; Li, Ying; Zuo, Jian-Ping
Journal of Medicinal Chemistry, 2005 , vol. 48, # 14 p. 4608 - 4617
反应条件
(i) NaNO2, aq. HCl, (ii) aq. H2SO4; Multistep reaction;
参考文献
Dunwell,D.W. et al.
Journal of Medicinal Chemistry, 1975 , vol. 18, # 1 p. 53 - 58
反应条件
1: HNO3 / acetic acid 2: SnCl2, aq. HCl / ethanol 3: Py 4: aq. HCl / 2.5 h / Heating View Scheme
参考文献
Dunwell,D.W. et al.
Journal of Medicinal Chemistry, 1975 , vol. 18, # 1 p. 53 - 58
反应条件
sodium hydroxide 5 h; Heating;
参考文献
Yang, Zhong-Shun; Zhou, Wen-Liang; Sui, Yi; Wang, Jun-Xia; Wu, Jin-Ming; Zhou, Yu; Zhang, Yu; He, Pei-Lan; Han, Ji-Ye; Tang, Wei; Li, Ying; Zuo, Jian-Ping
Journal of Medicinal Chemistry, 2005 , vol. 48, # 14 p. 4608 - 4617
反应条件
1: HNO3 / acetic acid
2: SnCl2, aq. HCl / ethanol
3: Py
4: NaN3, NH4Cl / dimethylformamide / 24 h / 125 °C
View Scheme
参考文献
Dunwell,D.W. et al.
Journal of Medicinal Chemistry, 1975 , vol. 18, # 1 p. 53 - 58
反应条件
1: HNO3 / acetic acid
2: SnCl2, aq. HCl / ethanol
3: aq. HCl / Heating
4: Py
View Scheme
参考文献
Dunwell,D.W. et al.
Journal of Medicinal Chemistry, 1975 , vol. 18, # 1 p. 53 - 58
反应条件
1: HNO3 / acetic acid
2: SnCl2, aq. HCl / ethanol
3: (i) Py, (ii) aq. HCl
View Scheme
参考文献
Dunwell,D.W. et al.
Journal of Medicinal Chemistry, 1975 , vol. 18, # 1 p. 53 - 58
