5-溴甲基-1,2,3-三甲氧基苯合成路线 （共 19 条）
反应条件
sodium tetrahydroborate in methanol T=20°C;
参考文献
Azzena, Ugo; Dettori, Giovanna; Idini, Maria Vittoria; Pisano, Luisa; Sechi, Grazia
Tetrahedron, 2003 , vol. 59, # 40 p. 7961 - 7966
反应条件
1: 73 percent / 2.17 h / 140 - 180 °C 2: 76 percent / NaH; 15-crown-5 / tetrahydrofuran View Scheme
参考文献
Ao, Junli; Chen, Yuanmou; Xu, Xiaoling; Zhang, Xu; Yu, Yue; Yu, Peng; Hua, Erbing
Asian Journal of Chemistry, 2014 , vol. 26, # 7 p. 2092 - 2098
反应条件
in dimethyl sulfoxide Ambient temperature;
参考文献
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, , vol. 21, # 3 p. 173 - 175
反应条件
1: toluene 2: n-BuLi / tetrahydrofuran 3: (n-Bu)4NF / tetrahydrofuran View Scheme
参考文献
Bedford, Simon B.; Quarterman, Charmaine P.; Rathbone, Daniel L.; Slack, John A.; Griffin, Roger J.; Stevens, Malcolm F. G.
Bioorganic and Medicinal Chemistry Letters, 1996 , vol. 6, # 2 p. 157 - 160
反应条件
1: toluene
2: n-BuLi / tetrahydrofuran
3: (n-Bu)4NF / tetrahydrofuran
5: MCPBA
View Scheme
参考文献
Bedford, Simon B.; Quarterman, Charmaine P.; Rathbone, Daniel L.; Slack, John A.; Griffin, Roger J.; Stevens, Malcolm F. G.
Bioorganic and Medicinal Chemistry Letters, 1996 , vol. 6, # 2 p. 157 - 160
反应条件
1.1: 73 percent / 2.17 h / 140 - 180 °C
2.1: 93 percent / NaH; 15-crown-5 / tetrahydrofuran
3.1: Na / tetrahydrofuran / 7 h / 20 °C
3.2: 78 percent / H2O / tetrahydrofuran / 0 °C
View Scheme
参考文献
Azzena, Ugo; Dettori, Giovanna; Idini, Maria Vittoria; Pisano, Luisa; Sechi, Grazia
Tetrahedron, 2003 , vol. 59, # 40 p. 7961 - 7966
参考文献
Narasimhan; Aidhen; Sunder
Journal of the Indian Chemical Society, 1989 , vol. 66, # 8-10 p. 703 - 709
反应条件
in tetrahydrofuran
24 h; Heating;
参考文献
Olszewski; Marshalla; Sabat; Sundberg
Journal of Organic Chemistry, 1994 , vol. 59, # 15 p. 4285 - 4296
反应条件
1: 83 percent / dimethylformamide / 3.5 h / 0 °C
2: 65 percent / KOH
View Scheme
参考文献
Reimann; Hoglmuller
Archiv der Pharmazie, 1985 , vol. 318, # 6 p. 487 - 495
