2-溴-5-BOC-氨基砒啶合成路线 （共 3 条）
反应条件
1: 5-amino-2-bromopyridine With sodium hexamethyldisilazane in tetrahydrofuran T=0°C; 0.0833333 h; 2: di-tert-butyl dicarbonate in tetrahydrofuran T=20°C; 0.5 h; 3: With hydrogenchloride in tetrahydrofuran; water pH=7 - 8;
参考文献
Sun, Chongqing; Ewing, William R.; Sulsky, Richard B.; Huang, Yanting
Patent: US2006/155126 A1, 2006 ;
Location in patent: Page/Page column 11 ;
US 20060155126 A1
反应条件
sodium hexamethyldisilazane in tetrahydrofuran T=0 - 25°C; Inert atmosphere;
参考文献
Young, Brandon M.; Hyatt, Janice L.; Bouck, David C.; Chen, Taosheng; Hanumesh, Parimala; Price, Jeanine; Boyd, Vincent A.; Potter, Philip M.; Webb, Thomas R.
Journal of Medicinal Chemistry, 2010 , vol. 53, # 24 p. 8709 - 8715
反应条件
potassium carbonate; {PdCl2[(t-Bu)2PCl]2} in tetrahydrofuran; methanol
T=20 - 70°C; 1 h;
参考文献
Sun, Chongqing; Ewing, William R.; Sulsky, Richard B.; Huang, Yanting
Patent: US2006/155126 A1, 2006 ;
Location in patent: Page/Page column 11 ;
US 20060155126 A1
