(3S)-4-{[叔-丁基(二甲基)硅烷基]氧基}-3-甲基丁基苯基砜合成路线 （共 7 条）
反应条件
1: (-)-(3S)-4-{[tert-butyl(dimethyl)silyl]oxy}-3-methylbutyl phenyl sulfone With 18-crown-6 ether; potassium hexamethylsilazane in tetrahydrofuran T=-78°C; 1 h; 2: 4-((1E,3S,5Z)-3-{[tert-butyl(dimethyl)silyl]oxy}-7-iodo-2,6-dimethylhepta-1,5-dienyl)-2-methyl-1,3-thiazole in tetrahydrofuran T=-78°C; 1 h; Further stages.;
参考文献
Mulzer, Johann; Mantoulidis, Andreas; Oehler, Elisabeth
Journal of Organic Chemistry, 2000 , vol. 65, # 22 p. 7456 - 7467
→
193146-53-1(3S,6R,7S,8S,12Z,15S,16E)-3,7,15-三-{[叔-丁基(二甲基)硅烷基]氧基}-1-羟基-4,4,6,8,12,16-六甲基-17-(2-甲基-1,3-噻唑-4-基)十七-12,16-二烯-5-酮
反应条件
1.1: 18-crown-6; KHMDS / tetrahydrofuran / 1 h / -78 °C 1.2: 93 percent / tetrahydrofuran / 1 h / -78 °C 2.1: 65 percent / Na2HPO4; Na-Hg amalgam / methanol; tetrahydrofuran / -15 - 20 °C 3.1: 99 percent / CSA / methanol; CH2Cl2 / 5 h / 0 - 10 °C 4.1: Dess-Martin periodinane; pyridine / CH2Cl2 / 4 h / 20 °C 5.1: LDA / tetrahydrofuran / 1 h / -78 - -35 °C 5.2: tetrahydrofuran / 1.5 h / -95 - -80 °C 6.1: 99 percent / 2,6-lutidine / CH2Cl2 / 3 h / 0 °C 7.1: 87 percent / CSA / methanol; CH2Cl2 / 4 h / 0 °C View Scheme
参考文献
Mulzer, Johann; Mantoulidis, Andreas; Oehler, Elisabeth
Tetrahedron Letters, 1998 , vol. 39, # 47 p. 8633 - 8636
反应条件
1.1: 18-crown-6; KHMDS / tetrahydrofuran / 1 h / -78 °C 1.2: 93 percent / tetrahydrofuran / 1 h / -78 °C 2.1: 65 percent / Na2HPO4; Na-Hg amalgam / methanol; tetrahydrofuran / -15 - 20 °C 3.1: 99 percent / CSA / methanol; CH2Cl2 / 5 h / 0 - 10 °C 4.1: Dess-Martin periodinane; pyridine / CH2Cl2 / 4 h / 20 °C 5.1: LDA / tetrahydrofuran / 1 h / -78 - -35 °C 5.2: tetrahydrofuran / 1.5 h / -95 - -80 °C 6.1: 99 percent / 2,6-lutidine / CH2Cl2 / 3 h / 0 °C 7.1: 87 percent / CSA / methanol; CH2Cl2 / 4 h / 0 °C 8.1: Dess-Martin periodinane; Py / CH2Cl2 / 2 h / 20 °C 9.1: 380 mg / NaClO2; NaH2PO4 / 2-methyl-propan-2-ol; various solvent(s); H2O / 3 h 10.1: 55 percent / TBAF / tetrahydrofuran / 10 h / 20 °C 11.1: 69 percent / N-ethyl-N'-(3-(dimethylamino)propyl)carbodiimide *HCl; DMAP; DMAP*HCl / CHCl3 / 17 h / Heating 12.1: 96 percent / HF*Py; Py / tetrahydrofuran / 36 h / 0 - 20 °C 13.1: m-CPBA / CHCl3 / 5 h / -18 °C View Scheme
参考文献
Mulzer, Johann; Mantoulidis, Andreas; Oehler, Elisabeth
Tetrahedron Letters, 1998 , vol. 39, # 47 p. 8633 - 8636
反应条件
1.1: 18-crown-6; KHMDS / tetrahydrofuran / 1 h / -78 °C 1.2: 93 percent / tetrahydrofuran / 1 h / -78 °C 2.1: 65 percent / Na2HPO4; Na-Hg amalgam / methanol; tetrahydrofuran / -15 - 20 °C 3.1: 99 percent / CSA / methanol; CH2Cl2 / 5 h / 0 - 10 °C 4.1: Dess-Martin periodinane; pyridine / CH2Cl2 / 4 h / 20 °C 5.1: LDA / tetrahydrofuran / 1 h / -78 - -35 °C 5.2: tetrahydrofuran / 1.5 h / -95 - -80 °C 6.1: 99 percent / 2,6-lutidine / CH2Cl2 / 3 h / 0 °C 7.1: 87 percent / CSA / methanol; CH2Cl2 / 4 h / 0 °C 8.1: Dess-Martin periodinane; Py / CH2Cl2 / 2 h / 20 °C 9.1: 380 mg / NaClO2; NaH2PO4 / 2-methyl-propan-2-ol; various solvent(s); H2O / 3 h 10.1: 55 percent / TBAF / tetrahydrofuran / 10 h / 20 °C 11.1: 69 percent / N-ethyl-N'-(3-(dimethylamino)propyl)carbodiimide *HCl; DMAP; DMAP*HCl / CHCl3 / 17 h / Heating 12.1: 96 percent / HF*Py; Py / tetrahydrofuran / 36 h / 0 - 20 °C View Scheme
参考文献
Mulzer, Johann; Mantoulidis, Andreas; Oehler, Elisabeth
Tetrahedron Letters, 1998 , vol. 39, # 47 p. 8633 - 8636
→
193146-51-9(3S,6R,7S,8S,12Z,15S,16E)-1,3,7,15-四-{[叔-丁基(二甲基)硅烷基]氧基}-4,4,6,8,12,16-六甲基-17-(2-甲基-1,3-噻唑-4-基)十七-12,16-二烯-5-酮
反应条件
1.1: 18-crown-6; KHMDS / tetrahydrofuran / 1 h / -78 °C
1.2: 93 percent / tetrahydrofuran / 1 h / -78 °C
2.1: 65 percent / Na2HPO4; Na-Hg amalgam / methanol; tetrahydrofuran / -15 - 20 °C
3.1: 99 percent / CSA / methanol; CH2Cl2 / 5 h / 0 - 10 °C
4.1: Dess-Martin periodinane; pyridine / CH2Cl2 / 4 h / 20 °C
5.1: LDA / tetrahydrofuran / 1 h / -78 - -35 °C
5.2: tetrahydrofuran / 1.5 h / -95 - -80 °C
6.1: 99 percent / 2,6-lutidine / CH2Cl2 / 3 h / 0 °C
View Scheme
参考文献
Mulzer, Johann; Mantoulidis, Andreas; Oehler, Elisabeth
Tetrahedron Letters, 1998 , vol. 39, # 47 p. 8633 - 8636
→
193146-63-3(3S,6R,7S,8S,12Z,15S,16E)-3,7,15-三-{[叔-丁基(二甲基)硅烷基]氧基}-4,4,6,8,12,16-六甲基-17-(2-甲基-1,3-噻唑-4-基)-5-氧代-十七-12,16-二烯酸
反应条件
1.1: 18-crown-6; KHMDS / tetrahydrofuran / 1 h / -78 °C
1.2: 93 percent / tetrahydrofuran / 1 h / -78 °C
2.1: 65 percent / Na2HPO4; Na-Hg amalgam / methanol; tetrahydrofuran / -15 - 20 °C
3.1: 99 percent / CSA / methanol; CH2Cl2 / 5 h / 0 - 10 °C
4.1: Dess-Martin periodinane; pyridine / CH2Cl2 / 4 h / 20 °C
5.1: LDA / tetrahydrofuran / 1 h / -78 - -35 °C
5.2: tetrahydrofuran / 1.5 h / -95 - -80 °C
6.1: 99 percent / 2,6-lutidine / CH2Cl2 / 3 h / 0 °C
7.1: 87 percent / CSA / methanol; CH2Cl2 / 4 h / 0 °C
8.1: Dess-Martin periodinane; Py / CH2Cl2 / 2 h / 20 °C
9.1: 380 mg / NaClO2; NaH2PO4 / 2-methyl-propan-2-ol; various solvent(s); H2O / 3 h
View Scheme
参考文献
Mulzer, Johann; Mantoulidis, Andreas; Oehler, Elisabeth
Tetrahedron Letters, 1998 , vol. 39, # 47 p. 8633 - 8636
→
193146-49-5(3S,6R,7S,8S,12Z,15S,16E)-1,3,15-三-{[叔-丁基(二甲基)硅烷基]氧基}-7-羟基-4,4,6,8,12,16-六甲基-17-(2-甲基-1,3-噻唑-4-基)十七烷基-12,16-二烯-5-酮
反应条件
1.1: 18-crown-6; KHMDS / tetrahydrofuran / 1 h / -78 °C
1.2: 93 percent / tetrahydrofuran / 1 h / -78 °C
2.1: 65 percent / Na2HPO4; Na-Hg amalgam / methanol; tetrahydrofuran / -15 - 20 °C
3.1: 99 percent / CSA / methanol; CH2Cl2 / 5 h / 0 - 10 °C
4.1: Dess-Martin periodinane; pyridine / CH2Cl2 / 4 h / 20 °C
5.1: LDA / tetrahydrofuran / 1 h / -78 - -35 °C
5.2: tetrahydrofuran / 1.5 h / -95 - -80 °C
View Scheme
参考文献
Mulzer, Johann; Mantoulidis, Andreas; Oehler, Elisabeth
Tetrahedron Letters, 1998 , vol. 39, # 47 p. 8633 - 8636
