2-氨基-1,7-二氢-7-(2-丙烯-1-基)-6H-嘌呤-6-酮合成路线 （共 6 条）
反应条件
1: in dimethyl sulfoxide T=20°C; 18 h; 2: With hydrogenchloride in water; dimethyl sulfoxide 0.75 h;
参考文献
SMITHKLINE BEECHAM CORPORATION
Patent: WO2005/77950 A2, 2005 ;
Location in patent: Page/Page column 20; 26 ;
WO 2005/077950 A2
反应条件
1: in dimethyl sulfoxide T=20°C; 18 h; 2: With hydrogenchloride; water in dimethyl sulfoxide 0.75 h; 3: With sodium hydroxide in methanol; water; dimethyl sulfoxide
参考文献
SMITHKLINE BEECHAM CORPORATION
Patent: WO2006/45564 A1, 2006 ;
Location in patent: Page/Page column 30 ;
WO 2006/045564 A1
反应条件
tetrabutyl ammonium fluoride in acetonitrile T=50°C; 2 h;
参考文献
Gundersen, Lise-Lotte; Benneche, Tore; Rise, Frode; Gogoll, Adolf; Undheim, Kjell
Acta Chemica Scandinavica, 1992 , vol. 46, # 8 p. 761 - 771
反应条件
1: With formic acid T=75°C; 2 h; 2: With ethanol 0.5 h; Reflux;
参考文献
Maryska, Michal; Chudikova, Nadezda; Kotek, Vladislav; Dvorak, Dalimil; Tobrman, Tomas
Monatshefte fur Chemie, 2013 , vol. 144, # 4 p. 501 - 507
反应条件
1: 1.) LiH, 2.) tetrakis(triphenylphosphine)palladium / 1.) DMF, RT, 30 min, 2.) DMSO, 45 deg C, 22 h 2: 77 percent / tetrabutylammonium fluoride / acetonitrile / 2 h / 50 °C View Scheme
参考文献
Gundersen, Lise-Lotte; Benneche, Tore; Rise, Frode; Gogoll, Adolf; Undheim, Kjell
Acta Chemica Scandinavica, 1992 , vol. 46, # 8 p. 761 - 771
反应条件
1: 1.) NaH / 1.) dioxane, RT, 15 min, 2.) dioxane, reflux, 19 h 2: 1.) LiH, 2.) tetrakis(triphenylphosphine)palladium / 1.) DMF, RT, 30 min, 2.) DMSO, 45 deg C, 22 h 3: 77 percent / tetrabutylammonium fluoride / acetonitrile / 2 h / 50 °C View Scheme
参考文献
Gundersen, Lise-Lotte; Benneche, Tore; Rise, Frode; Gogoll, Adolf; Undheim, Kjell
Acta Chemica Scandinavica, 1992 , vol. 46, # 8 p. 761 - 771
