3-甲基-2-苯并恶唑酮合成路线 （共 63 条）
反应条件
1: 70 percent / polyphosphoric acid 2: 85 percent / NaOH 3: 80 percent / C2H5ONa / dimethylsulfoxide / 3 h / Ambient temperature View Scheme
参考文献
European Journal of Medicinal Chemistry, , vol. 24, p. 55 - 60
反应条件
1: 80 percent / polyphosphoric acid / 1.5 h / 100 °C
2: 70 percent / aq. sodium hydroxide / Heating
3: 75 percent / sodium hydrogencarbonate / butan-2-one; H2O / 8 h / 90 °C
4: 80 percent / acetic anhydride / 3 h / 90 - 100 °C
View Scheme
参考文献
Moussavi; Depreux; Lesieur; Cotelle; Sauzieres; Plancke; Fruchart
Farmaco, 1991 , vol. 46, # 2 p. 339 - 355
反应条件
aluminium trichloride; N,N-dimethyl-formamide
T=80°C; 3 h; Yields of byproduct given;
参考文献
Aichaoui, Hocine; Poupaert, Jacques H.; Lesieur, Daniel; Henichart, Jean-Pierre
Bulletin des Societes Chimiques Belges, 1992 , vol. 101, # 12 p. 1053 - 1060
反应条件
PPA
T=120°C; 0.083 h;
参考文献
Merdji, B.; Lesieur, D.; Lespagnol, C.; Barbry, D.; Couturier, D.
Journal of Heterocyclic Chemistry, 1981 , vol. 18, p. 1223 - 1227
反应条件
1: 85 percent / PPA / 1.75 h / 140 - 150 °C
2: 68 percent / AlCl3/DMF / dimethylformamide / 18 h / 110 °C
View Scheme
参考文献
Merdji, B.; Lesieur, D.; Lespagnol, C.; Barbry, D.; Couturier, D.
Journal of Heterocyclic Chemistry, 1981 , vol. 18, p. 1223 - 1227
反应条件
PPA
T=70°C; 5 h; var. time, var. temperature; Product distribution;
参考文献
Merdji, B.; Lesieur, D.; Lespagnol, C.; Barbry, D.; Couturier, D.
Journal of Heterocyclic Chemistry, 1981 , vol. 18, p. 1223 - 1227
参考文献
Fujisawa Pharmaceutical Co., Ltd.
Patent: US4621084 A1, 1986 ;
参考文献
Fujisawa Pharmaceutical Co., Ltd.
Patent: US4621084 A1, 1986 ;
反应条件
N-chloro-succinimide; acetic acid
120 h; Ambient temperature;
参考文献
Gershon, H.; Clarke, D. D.; Gershon, M.
Monatshefte fuer Chemie, 1993 , vol. 124, # 4 p. 367 - 380
反应条件
1: 75 percent / polyphosphoric acid / 4 h / 100 °C
2: 90 percent / aq. sodium hydroxide / Heating
View Scheme
参考文献
Moussavi; Depreux; Lesieur; Cotelle; Sauzieres; Plancke; Fruchart
Farmaco, 1991 , vol. 46, # 2 p. 339 - 355
