3,4-二甲基苯-1-羰酰氯合成路线 （共 20 条）
反应条件
diethyl ether Erwaermen einer Loesung des Reaktionsprodukts in Dioxan mit Silberoxid, Natriumcarbonat und Natriumthiosulfat in Wasser;
参考文献
Skinner et al.
Journal of Organic Chemistry, 1959 , vol. 24, p. 403
反应条件
AlCl3, aluminium chloride in 1,2-dichloro-ethane T=20°C; Friedel-Crafts acylation;
参考文献
Wright, Karen; Moretto, Alessandro; Crisma, Marco; Wakselman, Michel; Mazaleyrat, Jean-Paul; Formaggio, Fernando; Toniolo, Claudio
Organic and Biomolecular Chemistry, 2010 , vol. 8, # 14 p. 3281 - 3286
反应条件
T=130°C; anschliessendes Erwaermen mit wss. Natronlauge;
参考文献
Geigy A.G.
Patent: CH243012 , 1944 ;
反应条件
copper; chlorobenzene anschliessendes Erwaermen mit wss. Natronlauge;
参考文献
Geigy A.G.
Patent: CH243012 , 1944 ;
参考文献
Morgan; Coulson
Journal of the Chemical Society, 1931 , p. 2323,2331
Journal of the Society of Chemical Industry, London, 1934 , vol. 53, p. 71 T
反应条件
benzyl-N,N-dimethylamine; palladium diacetate in toluene
T=100°C; 4 h;
参考文献
Spencer, Alwyn
Journal of Organometallic Chemistry, 1983 , vol. 247, # 1 p. 117 - 122
反应条件
1: 65 percent / palladium catalyst
2: 95 percent / CF3SO3H / 0.25 h / -30 °C
View Scheme
参考文献
Vasilyev; Walspurger; Haouas; Sommer; Pale; Rudenko
Organic and Biomolecular Chemistry, 2004 , vol. 2, # 23 p. 3483 - 3489
反应条件
in hexane; dichloromethane
参考文献
Hoechst Aktiengesellschaft
Patent: US4835318 A1, 1989 ;
反应条件
1: 81 percent / Et3N / dioxane / 5 h / Heating
2: 90 percent / 30 h / 140 °C
View Scheme
参考文献
Tarzia, Giorgio; Occelli, Emilio; Toja, Emilio; Barone, Domenico; Corsico, Nerina; et al.
Journal of Medicinal Chemistry, 1988 , vol. 31, # 6 p. 1115 - 1123
反应条件
1: 85 percent / 1N NaOH / H2O / 4 h / 15 - 20 °C
2: 82.5 percent / acetic anhydride / diisopropyl ether / 2 h / 70 °C
3: tetrahydrofuran / 3 h / 25 °C
View Scheme
参考文献
Makovec; Chiste; Bani; et al.
European Journal of Medicinal Chemistry, 1986 , vol. 21, # 1 p. 9 - 20
