2-氨基-3-硝基-6-甲基吡啶合成路线 （共 25 条）
反应条件
sulfuric acid; water; sodium nitrite T=0°C; 16 h;
参考文献
Beijing Yiling Bioengineering Co., Ltd.
Patent: EP2366691 A1, 2011 ;
Location in patent: Page/Page column 11 ;
反应条件
hydrogenchloride; sodium nitrite Diazotization;
参考文献
Parker; Shive
Journal of the American Chemical Society, 1947 , vol. 69, p. 63,66
反应条件
hydrogenchloride; sodium nitrite Diazotization;
参考文献
Parker; Shive
Journal of the American Chemical Society, 1947 , vol. 69, p. 63,66
反应条件
1: sodium nitrite; aqueous sulfuric acid / Diazotization.und Erwaermen des Reaktionsloesung 2: phosphorus (V)-chloride; phosphoryl chloride View Scheme
参考文献
Beijing Yiling Bioengineering Co., Ltd.
Patent: EP2366691 A1, 2011 ;
反应条件
1: 38.5 percent / dimethylformamide / 16 h / 140 °C 2: 1.8 g / potassium carbonate; potassium permanganate / H2O; 2-methyl-propan-2-ol / 3 h 3: 0.40 g / sulfuric acid / 4 h / Heating 4: 96 percent / H2 / platinum(IV) oxide / ethanol / 0.5 h / 1551.44 Torr View Scheme
参考文献
Chand, Pooran; Kotian, Pravin L.; Morris, Philip E.; Bantia, Shanta; Walsh, David A.; Babu, Yarlagadda S.
Bioorganic and Medicinal Chemistry, 2005 , vol. 13, # 7 p. 2665 - 2678
反应条件
hydrazine in water T=110 - 120°C; 5 h;
参考文献
Russian Journal of Organic Chemistry, , vol. 45, # 1 p. 115 - 118
反应条件
1: sodium nitrite; aqueous hydrochloric acid / Diazotization 2: SnCl2; concentrated aqueous HCl View Scheme
参考文献
Parker; Shive
Journal of the American Chemical Society, 1947 , vol. 69, p. 63,66
反应条件
hydrogen; 5-palladium/activated carbon in methanol T=20°C; P=760.051 Torr; 2 h;
参考文献
ASTRAZENECA AB; ASTEX THERAPEUTICS
Patent: WO2006/65204 A1, 2006 ;
Location in patent: Page/Page column 96-97 ;
WO 2006/065204 A1
反应条件
1: 38.5 percent / dimethylformamide / 16 h / 140 °C 2: 1.8 g / potassium carbonate; potassium permanganate / H2O; 2-methyl-propan-2-ol / 3 h 3: 0.40 g / sulfuric acid / 4 h / Heating View Scheme
参考文献
Chand, Pooran; Kotian, Pravin L.; Morris, Philip E.; Bantia, Shanta; Walsh, David A.; Babu, Yarlagadda S.
Bioorganic and Medicinal Chemistry, 2005 , vol. 13, # 7 p. 2665 - 2678
反应条件
1: HCl, NaNO2 / Ambient temperature 2: 49 percent / dimethylformamide / 6 h / Heating 3: 96 percent / H2 / 10percent Pd/C / ethyl acetate / 7.5 h / 2700.2 Torr / Ambient temperature View Scheme
参考文献
Troschutz; Karger
Journal of Heterocyclic Chemistry, 1996 , vol. 33, # 6 p. 1815 - 1821
