2-羟基-4-甲基-5-硝基吡啶合成路线

MERZ PHARMA GMBH and CO. KGAA; HENRICH, Markus; ABEL, Ulrich; MULLER, Sibylle; KUBAS, Holger; MEYER, Udo; HECHENBERGER, Mirko; KAUSS, Valerjans; ZEMRIBO, Ronalds
Patent: WO2012/52451 A1, 2012 ;
Location in patent: Page/Page column 117-118 ;
WO 2012/052451 A1

21901-41-72-羟基-4-甲基-5-硝基吡啶

23056-33-92-氯-5-硝基-4-甲基吡啶+

17288-53-85-甲基-6-氮杂吲哚

参考文献

Pfizer Inc.
Patent: US5051412 A1, 1991 ;

21901-41-72-羟基-4-甲基-5-硝基吡啶

23056-33-92-氯-5-硝基-4-甲基吡啶+

17288-53-85-甲基-6-氮杂吲哚

参考文献

Pfizer Inc.
Patent: US5051412 A1, 1991 ;

21901-41-72-羟基-4-甲基-5-硝基吡啶

267875-30-92-氰基-4-甲基-5-硝基吡啶

参考文献

Sanderson, Philip E. J.; Stanton, Matthew G.; Dorsey, Bruce D.; Lyle, Terry A.; McDonough, Colleen; Sanders, William M.; Savage, Kelly L.; Naylor-Olsen, Adel M.; Krueger, Julie A.; Lewis, S. Dale; Lucas, Bobby J.; Lynch, Joseph J.; Yan, Youwei
Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 5 p. 795 - 798

21901-41-72-羟基-4-甲基-5-硝基吡啶

23056-47-52-溴-4-甲基-5-硝基吡啶

参考文献

Plewe, Michael B.; Butler, Scott L.; Dress, Klaus R.; Hu, Qiyue; Johnson, Ted W.; Kuehler, Jon E.; Kuki, Atsuo; Lam, Hieu; Liu, Wen; Nowlin, Dawn; Peng, Qinghai; Rahavendran, Sadayappan V.; Tanis, Steven P.; Tran, Khanh T.; Wang, Hai; Yang, Anle; Zhang, Junhu
Journal of Medicinal Chemistry, 2009 , vol. 52, # 22 p. 7211 - 7219