hydrogen bromide in water 4 h; Heating;

in (2S)-N-methyl-1-phenylpropan-2-amine hydrate; dichloromethane

1: LiAlH4 / tetrahydrofuran 2: 48percent HBr / Heating View Scheme

1: 18 g / Na2S*9H2O / 0.5 h 2: 13.4 g / 40percent CH3CO2OH / CHCl3 3: 5.9 g / 7 h / 230 °C 4: 5.4 g / NBS, AIBN / acetic anhydride / 1.5 h / Heating 5: 4.1 g / methanol / 2 h / Heating 6: 2.3 g / Et3N, diphenylphosphoryl azide / 6 h / Heating 7: 1.8 g / HCl / diethyl ether 8: 1.) NaNO2, HCl, 2.) CuCl, HCl / 1.) H2O, 0 deg C View Scheme