2-甲基-3-吲哚乙酸乙酯合成路线 （共 22 条）
反应条件
1: 2-methyl-1H-indole With n-butyllithium in tetrahydrofuran; hexanes
T=0°C;
2: With zinc(II) chloride in tetrahydrofuran; hexanes
T=20°C; 20 h;
3: ethyl bromoacetate in toluene
48 h;
参考文献
Desreumaux, Pierre; Bellinvia, Salvatore; Chavatte, Philippe; Baroni, Sergio
Patent: US2011/39808 A1, 2011 ;
Location in patent: Page/Page column 53 ;
参考文献
ELI LILLY AND COMPANY
Patent: EP1266897 A2, 2002 ;
Location in patent: Page 30 ;
反应条件
2,2'-azo-bisisobutyronitrile; tri-n-butyl-tin hydride in toluene
Heating;
参考文献
Bowman, W. Russell; Fletcher, Anthony J.; Lovell, Peter J.; Pedersen, Jan M.
Synlett, 2004 , # 11 p. 1905 - 1908
反应条件
ethanol; sulfuric acid
参考文献
Bullock; Fox
Journal of the American Chemical Society, 1951 , vol. 73, p. 5155
反应条件
1: 68 percent / triethylamine; 4-(dimethylamino)pyridine / CH2Cl2 / 0 - 20 °C
2: phosgene; DMF / CH2Cl2; toluene / 4 h / 20 °C
3: K-Selectride(R) / tetrahydrofuran / 3 h / 20 °C
4: 98 percent / Bu3SnH; AIBN / toluene / 1 h / Heating
View Scheme
参考文献
Bowman, W. Russell; Fletcher, Anthony J.; Pedersen, Jan M.; Lovell, Peter J.; Elsegood, Mark R.J.; Hernandez Lopez, Elena; McKee, Vickie; Potts, Graeme B.S.
Tetrahedron, 2007 , vol. 63, # 1 p. 191 - 203
反应条件
sulfuric acid in ethanol
10 h; Heating;
参考文献
Sen Gupta; Gupta
European Journal of Medicinal Chemistry, 1983 , vol. 18, # 2 p. 181 - 184
反应条件
in methanol
6 h; Heating;
参考文献
Vlaovic, Djordje; Cetkovic, Gordana; Juranic, Ivan; Balaz, Jelica; Lajsic, Stevan; Djokovic, Dejan
Monatshefte fuer Chemie, 1990 , vol. 121, # 11 p. 931 - 939
反应条件
1: phosgene; DMF / CH2Cl2; toluene / 4 h / 20 °C
2: K-Selectride(R) / tetrahydrofuran / 3 h / 20 °C
3: 98 percent / Bu3SnH; AIBN / toluene / 1 h / Heating
View Scheme
参考文献
Bowman, W. Russell; Fletcher, Anthony J.; Pedersen, Jan M.; Lovell, Peter J.; Elsegood, Mark R.J.; Hernandez Lopez, Elena; McKee, Vickie; Potts, Graeme B.S.
Tetrahedron, 2007 , vol. 63, # 1 p. 191 - 203
反应条件
1.1: 77 percent / Fe; HOAc / ethanol
2.1: 68 percent / Et3N; DMAP
3.1: COCl2; DMF / toluene; CH2Cl2 / 20 °C
4.1: K-Selectride / tetrahydrofuran
4.2: tetrahydrofuran / 20 °C
5.1: 98 percent / Bu3SnH; AIBN / toluene / Heating
View Scheme
参考文献
Bowman, W. Russell; Fletcher, Anthony J.; Lovell, Peter J.; Pedersen, Jan M.
Synlett, 2004 , # 11 p. 1905 - 1908
反应条件
1.1: 99 percent / tetrahydrofuran
2.1: 77 percent / Fe; HOAc / ethanol
3.1: 68 percent / Et3N; DMAP
4.1: COCl2; DMF / toluene; CH2Cl2 / 20 °C
5.1: K-Selectride / tetrahydrofuran
5.2: tetrahydrofuran / 20 °C
6.1: 98 percent / Bu3SnH; AIBN / toluene / Heating
View Scheme
参考文献
Bowman, W. Russell; Fletcher, Anthony J.; Lovell, Peter J.; Pedersen, Jan M.
Synlett, 2004 , # 11 p. 1905 - 1908
