3-(苯基氨基)丙酸甲酯合成路线 （共 19 条）
反应条件
T=100 - 110°C; 168 h; sealed tube;
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 29, # 9 p. 2525 - 2530
反应条件
T=100 - 110°C; 168 h;
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 29, # 9 p. 2525 - 2530
反应条件
T=100 - 110°C; 168 h; sealed tube;
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 29, # 9 p. 2525 - 2530
反应条件
pyridine T=20 - 100°C; 0.5 h; Inert atmosphere;
参考文献
Bunce, Richard A.; Cain, Nicholas R.; Cooper, John G.
Organic Preparations and Procedures International, 2013 , vol. 45, # 1 p. 28 - 43
反应条件
1: pyridine / 0.33 h / Heating
2: aq. HCl / dioxane / 3 h / Heating
3: 1.) PCl5, 2.) AlCl3 / 1.) benzene, from 5 deg C to 23 deg C, 30 min, 2.) benzene 15-20 deg C, 3.5 h
4: 83 percent / gl. AcOH, aq. HCl / 3.5 h / Heating
5: conc. HCl / propan-2-ol / 17 h / Heating
View Scheme
参考文献
Werbel, L. M.; Kesten, S. J.; Turner, W. R.
European Journal of Medicinal Chemistry, 1993 , vol. 28, # 11 p. 837 - 852
反应条件
1: pyridine / 0.33 h / Heating
2: aq. HCl / dioxane / 3 h / Heating
View Scheme
参考文献
Johnson; Woroch; Buell
Journal of the American Chemical Society, 1949 , vol. 71, p. 1901,1905
参考文献
Eastman Kodak Co.
Patent: US2470094 , 1945 ;
反应条件
hydrazine hydrate in ethanol
T=20°C; 12 h; Reflux;
参考文献
Yao, Ri-Sheng; Jiang, Lai-En; Wu, Sheng-Hua; Deng, Sheng-Song; Yang, Yang
Asian Journal of Chemistry, 2011 , vol. 23, # 9 p. 3792 - 3794
反应条件
potassium hydroxide; water in methanol
T=87°C; 0.5 h; microwave irradiation;
参考文献
Amore, Kristen M.; Leadbeater, Nicholas E.; Miller, Tyson A.; Schmink, Jason R.
Tetrahedron Letters, 2006 , vol. 47, # 48 p. 8583 - 8586
