2-甲基-1,3-噻唑-4-甲腈合成路线 （共 5 条）
反应条件
4-methyl-morpholine; thionyl chloride in N,N-dimethyl-formamide T=0 - 20°C; 5 h;
参考文献
Reiner, John E.; Siev, Daniel V.; Araldi, Gian-Luca; Cui, Jingrong Jean; Ho, Jonathan Z.; Reddy, Komandla Malla; Mamedova, Lala; Vu, Phong H.; Lee, Kuen-Shan S.; Minami, Nathaniel K.; Gibson, Tony S.; Anderson, Susanne M.; Bradbury, Annette E.; Nolan, Thomas G.; Semple, J. Edward
Bioorganic and Medicinal Chemistry Letters, 2002 , vol. 12, # 8 p. 1203 - 1208
反应条件
p-toluenesulfonic acid monohydrate in acetonitrile
反应条件
trichlorophosphate Heating / reflux;
参考文献
WO2007/138343 A1, ;
Page/Page column 7; 9 ;
WO 2007/138343 A1
反应条件
1: 89 percent / aq. NH3 / methanol / 16 h / 20 °C 2: 56 percent / SOCl2; NMM / dimethylformamide / 5 h / 0 - 20 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 12, # 8 p. 1203 - 1208
反应条件
1: 39 percent / NBS / CCl4 / 80 °C 2: NaN3 / dimethylformamide / 20 h / 20 °C 3: 80 percent / Ph3P / tetrahydrofuran; H2O / 20 h / 20 °C View Scheme
参考文献
Reiner, John E.; Siev, Daniel V.; Araldi, Gian-Luca; Cui, Jingrong Jean; Ho, Jonathan Z.; Reddy, Komandla Malla; Mamedova, Lala; Vu, Phong H.; Lee, Kuen-Shan S.; Minami, Nathaniel K.; Gibson, Tony S.; Anderson, Susanne M.; Bradbury, Annette E.; Nolan, Thomas G.; Semple, J. Edward
Bioorganic and Medicinal Chemistry Letters, 2002 , vol. 12, # 8 p. 1203 - 1208
