4-(溴甲基)-3-氯苯甲腈合成路线 （共 7 条）
反应条件
N-bromosuccinmide; 2,2'-azo-bisisobutyronitrile in tetrachloromethane 24 h; Reflux;
参考文献
Taylor, Steven J.; Soleymanzadeh, Fariba; Eldrup, Anne B.; Farrow, Neil A.; Muegge, Ingo; Kukulka, Alison; Kabcenell, Alisa K.; Lombaert, Stephane De
Bioorganic and Medicinal Chemistry Letters, 2009 , vol. 19, # 20 p. 5864 - 5868
反应条件
N-bromosuccinmide in tetrachloromethane; Petroleum ether
参考文献
Thorogood; Peter B.; Vinter; Jeremy G.
Patent: US4562199 A1, 1985 ;
反应条件
1: borane-THF / tetrahydrofuran / 20 °C 2: tetrakis(triphenylphosphine) palladium(0) / N,N-dimethyl-formamide / 100 °C 3: triphenylphosphine; carbon tetrabromide / dichloromethane / 2.5 h / 5 - 20 °C View Scheme
参考文献
PROXIMAGEN LIMITED; MEO, Paul; STEWART, Alison; HOBBS, Christopher
Patent: WO2014/20351 A1, 2014 ;
反应条件
1: tetrakis(triphenylphosphine) palladium(0) / N,N-dimethyl-formamide / 100 °C 2: triphenylphosphine; carbon tetrabromide / dichloromethane / 2.5 h / 5 - 20 °C View Scheme
参考文献
PROXIMAGEN LIMITED; MEO, Paul; STEWART, Alison; HOBBS, Christopher
Patent: WO2014/20351 A1, 2014 ;
反应条件
water; hydrogen bromide
T=100°C;
参考文献
ARGENTA DISCOVERY LTD.
Patent: WO2007/36743 A2, 2007 ;
Location in patent: Page/Page column 145-16 ;
WO 2007/036743 A2
反应条件
1: With ethanol; sodium
2: 2-Nitropropane; 4-bromomethyl-3-chlorobenzonitrile
参考文献
THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL
Patent: EP1719767 A1, 2006 ;
Location in patent: Page/Page column 24-28; 41 ;
反应条件
2-Nitropropane; sodium ethanolate
参考文献
Patrick, Donald A.; Bakunov, Stanislav A.; Bakunova, Svetlana M.; Kumar, E.V.K. Suresh; Lombardy, Richard J.; Jones, Susan Kilgore; Bridges, Arlene S.; Zhirnov, Oksana; Hall, James Edwin; Wenzler, Tanja; Brun, Reto; Tidwell, Richard R.
Journal of Medicinal Chemistry, 2007 , vol. 50, # 10 p. 2468 - 2485
