3,5-二溴-2-羟基吡嗪合成路线 （共 2 条）
反应条件
1: With sulfuric acid; acetic acid T=15 - 25°C; 2: With sodium nitrite in water T=10 - 15°C; 2.5 h;
参考文献
PFIZER INC.; NINKOVIC, Sacha; BRAGANZA, John Frederick; COLLINS, Michael Raymond; KATH, John Charles; LI, Hui; RICHTER, Daniel Tyler
Patent: WO2010/16005 A1, 2010 ;
Location in patent: Page/Page column 144 ;
WO 2010/016005 A1
反应条件
in tetrahydrofuran; diethyl ether T=0 - 20°C;
参考文献
PFIZER INC.; NINKOVIC, Sacha; BRAGANZA, John Frederick; COLLINS, Michael Raymond; KATH, John Charles; LI, Hui; RICHTER, Daniel Tyler
Patent: WO2010/16005 A1, 2010 ;
Location in patent: Page/Page column 144 ;
WO 2010/016005 A1
