N-叔丁氧羰基-S-三苯甲基-L-半胱氨酸合成路线 （共 12 条）
反应条件
1: With sodium hydroxide in water T=20°C; 24 h; 2: With hydrogenchloride in water pH=2;
参考文献
Venkateswara Rao, Boddu; Dhokale, Snehal; Rajamohanan, Pattuparambil R.; Hotha, Srinivas
Chemical Communications, 2013 , vol. 49, # 92 p. 10808 - 10810
反应条件
1: 89 percent / dimethylformamide / 48 h / 20 °C 2: Et3N / methanol / 1.5 h / Heating View Scheme
参考文献
Organic Letters, , vol. 7, # 13 p. 2615 - 2618
反应条件
1.1: trifluoroacetic acid / 2 h 1.2: 0 °C / pH 5 - 6 2.1: sodium hydroxide / water / 24 h / 20 °C 2.2: pH 2 View Scheme
参考文献
European Journal of Medicinal Chemistry, , vol. 50, p. 383 - 392
参考文献
Chemische Berichte, , vol. 102, p. 1048 - 1052
反应条件
(i) CF3CO2H, (ii) /BRN= 2217296/, aq. NaOH, dioxane; Multistep reaction;
参考文献
Canadian Journal of Chemistry, , vol. 57, p. 1388 - 1396
反应条件
in dichloromethane T=-30°C; 3 h;
参考文献
Matsueda, Rei; Higashida, Susumu; Ridge, Richard J.; Matsueda, Gary R.
Chemistry Letters, 1982 , p. 921 - 924
反应条件
[bis(acetoxy)iodo]benzene in dichloromethane 1.5 h; Ambient temperature;
参考文献
Tetrahedron Letters, , vol. 25, # 37 p. 4153 - 4156
反应条件
1: N-[(1,1-dimethylethoxy)carbonyl]-S-trityl-L-cysteine With 4-methyl-morpholine; isobutyl chloroformate in dichloromethane T=-15°C; 0.25 h; 2: O,N-dimethyl-hydroxylamine hydrochloride in dichloromethane T=20°C; 16 h;
参考文献
Dose, Christian; Seitz, Oliver
Organic Letters, 2005 , vol. 7, # 20 p. 4365 - 4368
反应条件
1: N-methylpiperidine / CH2Cl2 / 0.08 h / -20 °C 2: N-methylpiperidine / CH2Cl2 View Scheme
参考文献
Graham, Samuel L.; deSolms, S. Jane; Giuliani, Elizabeth A.; Kohl, Nancy E.; Mosser, Scott D.; et al.
Journal of Medicinal Chemistry, 1994 , vol. 37, # 6 p. 725 - 732
反应条件
dicyclohexyl-carbodiimide in acetonitrile
T=0 - 20°C; 14 h; Inert atmosphere;
参考文献
Silvia, Vertuani; Baldisserotto, Anna; Scalambra, Emanuela; Malisardi, Gemma; Durini, Elisa; Manfredini, Stefano
European Journal of Medicinal Chemistry, 2012 , vol. 50, p. 383 - 392
