in 1-methyl-pyrrolidin-2-one T=80°C; 0.0138889 h; microwave irradiation;

1: 2-chloro-pyrazine With potassium tert-butylate; thiourea in dimethyl sulfoxide 3 h; UV-irradiation; 2: methyl iodide in water; dimethyl sulfoxide

rat liver microsomes in phosphate buffer T=37°C; Methylation; pH=7.5; 0.5 h; Enzymatic reaction; Enzyme kinetics;

tetrakis(triphenylphosphine) palladium(0) in tetrahydrofuran T=55 - 60°C; Substitution; benzylation; 1 h;

1: p-methoxybenzyl chloride With lithium chloride; zinc Inert atmosphere; 2: 2-(methylmercapto)pyrazine With bis(acetylacetonate)nickel(II); bis[2-(diphenylphosphino)phenyl] ether in tetrahydrofuran T=25°C; Inert atmosphere;

1: 2-(methylmercapto)pyrazine With bis(acetylacetonate)nickel(II); bis[2-(diphenylphosphino)phenyl] ether in tetrahydrofuran 0.166667 h; Inert atmosphereLarge scale reaction; 2: C8H9ClOZn*ClLi in tetrahydrofuran T=25°C; 15 h; Inert atmosphere;