5-氨基-5-脱氧-2,3-O-(1-甲基亚乙基)-腺苷酸合成路线 （共 18 条）
反应条件
hydrazine hydrate in ethanol 2 h; Heating;
参考文献
Reeve, Anne M.; Townsend, Craig A.
Tetrahedron, 1998 , vol. 54, # 52 p. 15959 - 15974
反应条件
palladium 10 on activated carbon; hydrogen in ethanol T=20°C; 16 h;
参考文献
Moreau, Christelle; Kirchberger, Tanja; Swarbrick, Joanna M.; Bartlett, Stephen J.; Fliegert, Ralf; Yorgan, Timur; Bauche, Andreas; Harneit, Angelika; Guse, Andreas H.; Potter, Barry V. L.
Journal of Medicinal Chemistry, 2013 , vol. 56, # 24 p. 10079 - 10102
反应条件
1: 100 percent / DBU / dioxane / 3 h / 20 °C 2: 90 percent / NaN3; Bu4NI; 15-crown-5 / dioxane / 5 h / Heating 3: 84 percent / Ph3P / pyridine; aq. NH3 / 20 °C View Scheme
参考文献
Tetrahedron Letters, , vol. 42, # 18 p. 3153 - 3154
反应条件
2: pyridine / 2 h / 0 °C 3: Ambient temperature 4: 88 percent / NH3/EtOH / 1.5 h 5: 84 percent / NaN3 / dimethylformamide / 45 h / 80 °C 6: 66 percent / NH3, MeOH / 40 h / Ambient temperature 7: 70 percent / H2 / Pd-C / ethanol / 5 h / 2327.2 Torr View Scheme
参考文献
Nucleosides and Nucleotides, , vol. 14, # 1-2 p. 117 - 127
反应条件
1: NaN3 / dimethylformamide / 0.67 h / 65 - 68 °C 2: conc. NH4OH, PPh3 / pyridine / 18 h / Ambient temperature View Scheme
参考文献
Helvetica Chimica Acta, , vol. 78, # 7 p. 1777 - 1784
反应条件
1: 72.3 percent / LiN3 / dimethylformamide / 2.25 h / 74 - 80 °C 2: H2 / Ra-Ni / Ambient temperature; pressure View Scheme
参考文献
Journal of Organic Chemistry, , vol. 45, # 5 p. 788 - 794
反应条件
1: 80 percent / NaN3 / dimethylformamide / 1 h / 80 °C 2: 90 percent / hydrogen / 10 percent Pd/C / ethanol / 5 h / 20 °C View Scheme
参考文献
Tetrahedron, , vol. 58, # 29 p. 5767 - 5771
反应条件
1: 93 percent / pyridine / 2 h / 0 °C 2: 80 percent / NaN3 / dimethylformamide / 1 h / 80 °C 3: 90 percent / hydrogen / 10 percent Pd/C / ethanol / 5 h / 20 °C View Scheme
参考文献
Tetrahedron, , vol. 58, # 29 p. 5767 - 5771
反应条件
1: Ambient temperature 2: 88 percent / NH3/EtOH / 1.5 h 3: 84 percent / NaN3 / dimethylformamide / 45 h / 80 °C 4: 66 percent / NH3, MeOH / 40 h / Ambient temperature 5: 70 percent / H2 / Pd-C / ethanol / 5 h / 2327.2 Torr View Scheme
参考文献
Nucleosides and Nucleotides, , vol. 14, # 1-2 p. 117 - 127
反应条件
1: 66 percent / NH3, MeOH / 40 h / Ambient temperature 2: 70 percent / H2 / Pd-C / ethanol / 5 h / 2327.2 Torr View Scheme
参考文献
Nucleosides and Nucleotides, , vol. 14, # 1-2 p. 117 - 127
