6-硝基-1H-吲唑-1-羧酸叔丁酯合成路线 （共 4 条）
反应条件
1: 6-nitro-1H-indazole With sodium hydrogencarbonate in tetrahydrofuran T=0°C; 0.5 h; 2: di-tert-butyl dicarbonate in tetrahydrofuran T=20°C; 2 h;
参考文献
Lee, Jeewoo; Tran, Phuong-Thao; Hoang, Van-Hai; Thorat, Shivaji A.; Kim, Sung Eun; Ann, Jihyae; Chang, Yu Jin; Nam, Dong Woo; Song, Hyundong; Mook-Jung, Inhee; Lee, Jiyoun
Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 13 p. 3821 - 3830
反应条件
hydrogen; palladium 10 on activated carbon in methanol 2 h; Inert atmosphere;
参考文献
Array Biopharma, Inc.
Patent: US2010/63066 A1, 2010 ;
Location in patent: Page/Page column 35 ;
反应条件
potassium carbonate in methanol; water 0.333333 h; Heating;
参考文献
Chakrabarty, Manas; Kundu, Taraknath; Harigaya, Yoshihiro
Synthetic Communications, 2006 , vol. 36, # 14 p. 2069 - 2077
反应条件
1: 86 percent / H2 / Pd 10percent/C
2: 52 percent / NaOAc / methanol / 0 - 20 °C
View Scheme
参考文献
Renodon-Corniere, Axelle; Dijols, Sylvie; Perollier, Celine; Lefevre-Groboillot, David; Boucher, Jean-Luc; Attias, Roger; Sari, Marie-Agnes; Stuehr, Dennis; Mansuy, Daniel
Journal of Medicinal Chemistry, 2002 , vol. 45, # 4 p. 944 - 954
