1: 74 percent / tetrahydrofuran; diethyl ether / 3 h / -78 °C 2: Cu(OAc)2*H2O, Zn / acetic acid; H2O / 4 h / Ambient temperature 3: NaBH4 / ethanol / 18 h / 60 °C 4: 77 percent / N-methylmorpholine / toluene / 1 h / 100 °C 5: 79 percent / HCl / dioxane / 3 h / Ambient temperature View Scheme