1-(6-溴-2-吡啶基)哌嗪合成路线 （共 3 条）
反应条件
trifluoroacetic acid in dichloromethane T=20°C; 0.5 h;
参考文献
Louerat, Frederic; Gros, Philippe; Fort, Yves
Tetrahedron, 2005 , vol. 61, # 20 p. 4761 - 4768
反应条件
1.1: n-butyllithium; 2-(dimethylamino)ethanol / toluene; hexane / 2.5 h / 20 °C 1.2: 95 percent / CBr4 / toluene; hexane; tetrahydrofuran / -78 - 0 °C 2.1: 60 mg / trifluoroacetic acid / CH2Cl2 / 0.5 h / 20 °C View Scheme
参考文献
Louerat, Frederic; Gros, Philippe; Fort, Yves
Tetrahedron, 2005 , vol. 61, # 20 p. 4761 - 4768
反应条件
1.1: 94 percent / triethylamine / dimethylformamide / 6 h / 20 °C 2.1: n-butyllithium; 2-(dimethylamino)ethanol / toluene; hexane / 2.5 h / 20 °C 2.2: 95 percent / CBr4 / toluene; hexane; tetrahydrofuran / -78 - 0 °C 3.1: 60 mg / trifluoroacetic acid / CH2Cl2 / 0.5 h / 20 °C View Scheme
参考文献
Louerat, Frederic; Gros, Philippe; Fort, Yves
Tetrahedron, 2005 , vol. 61, # 20 p. 4761 - 4768
