5,8-二甲氧基-[1,2,4]三唑[1,5-c]嘧啶-2-胺合成路线 （共 10 条）
反应条件
1: in toluene T=27 - 87°C; 2: in water; toluene T=40°C; 3: With hydroxylamine in water; toluene T=68 - 81°C; pH=4.44 - 7.40; pH-valueSolventTemperatureTimeReagent/catalyst;
参考文献
Dow AgroSciences LLC; Bland, Douglas C.; Hamilton, Christopher T.
Patent: US2014/81024 A1, 2014 ;
Location in patent: Paragraph 0027 ;
反应条件
in methanol; acetonitrile T=20°C; 1.5 h;
参考文献
DOW AGROSCIENCES LLC
Patent: US2011/295003 A1, 2011 ;
Location in patent: Page/Page column 5 ;
反应条件
in water; ethyl acetate T=20 - 50°C;
参考文献
US2011/295003 A1, ;
Page/Page column 5-6 ;
反应条件
bromocyane; sodium methylate in methanol; acetonitrile; tert-butyl alcohol T=0 - 41°C; 7 h;
参考文献
Dow AgroSciences LLC
Patent: US6362335 B1, 2002 ;
Location in patent: Page column 7 ;
反应条件
sodium methylate in acetonitrile; tert-butyl alcohol T=21 - 42°C; 5.2 h;
参考文献
Dow AgroSciences LLC
Patent: US6362335 B1, 2002 ;
Location in patent: Example 8 ;
反应条件
ethyl acrylate in methanol T=20°C; Cooling with ice;
参考文献
Bioorganic and Medicinal Chemistry, , vol. 17, # 12 p. 4230 - 4240
反应条件
1.1: 1-methyl-pyrrolidin-2-one / 2.5 h / 50 °C 2.1: hydroxylamine hydrochloride; triethylamine / acetonitrile / 2 h / 45 °C 2.2: 4 h / 5.8 - 76 °C View Scheme
反应条件
1: ethyl acetate / 10 h / Reflux 2: hydroxylamine hydrochloride; sodium hydrogencarbonate / water; tert-butyl alcohol / 5 h / 20 °C 3: acetonitrile; methanol / 1.5 h / 20 °C View Scheme
反应条件
1: hydroxylamine hydrochloride; sodium hydrogencarbonate / water; tert-butyl alcohol / 5 h / 20 °C 2: acetonitrile; methanol / 1.5 h / 20 °C View Scheme
反应条件
1: ethyl acetate / 13.5 h / 78 °C 2: hydroxylamine hydrochloride; sodium hydroxide / ethyl acetate; water 3: ethyl acetate; water / 20 - 50 °C View Scheme
