(2R)-2-[[叔丁氧羰基]氨基]-4-碘丁酸甲酯合成路线 （共 4 条）
反应条件
sodium iodide in acetone 20 h; Ambient temperature;
参考文献
Zeng, Binqi; Wong, Kenny K.; Pompliano, David L.; Reddy, Sreelatha; Tanner, Martin E.
Journal of Organic Chemistry, 1998 , vol. 63, # 26 p. 10081 - 10086
反应条件
1.1: triethylamine / 4-(N,N-dimethlyamino)pyridine / water; tetrahydrofuran / 6 h / 20 °C / Cooling with ice 2.1: dicyclohexyl-carbodiimide / ethyl acetate / 4 h / 20 °C / Cooling with ice 3.1: sodium tetrahydroborate / water; tetrahydrofuran / 0.17 h / Cooling with ice 3.2: 20 °C 4.1: 1H-imidazole; triphenylphosphine; iodine / dichloromethane / 2 h / 20 °C View Scheme
参考文献
Zeng, Binqi; Wong, Kenny K.; Pompliano, David L.; Reddy, Sreelatha; Tanner, Martin E.
Journal of Organic Chemistry, 1998 , vol. 63, # 26 p. 10081 - 10086
反应条件
1.1: triethylamine / 4-(N,N-dimethlyamino)pyridine / water; tetrahydrofuran / 6 h / 20 °C / Cooling with ice 2.1: dicyclohexyl-carbodiimide / ethyl acetate / 4 h / 20 °C / Cooling with ice 3.1: sodium tetrahydroborate / water; tetrahydrofuran / 0.17 h / Cooling with ice 3.2: 20 °C 4.1: 1H-imidazole; triphenylphosphine; iodine / dichloromethane / 2 h / 20 °C View Scheme
参考文献
Sato, Seiichi; Futaki, Fumie; Yasuda, Reiko; Eto, Sachise; Suzuki, Yumiko; Tajima, Takaho; Eto, Yuzuru; Tahara, Yuki
Patent: US2012/282386 A1, 2012 ;
US 20120282386 A1
反应条件
1.1: dicyclohexyl-carbodiimide / ethyl acetate / 4 h / 20 °C / Cooling with ice 2.1: sodium tetrahydroborate / water; tetrahydrofuran / 0.17 h / Cooling with ice 2.2: 20 °C 3.1: 1H-imidazole; triphenylphosphine; iodine / dichloromethane / 2 h / 20 °C View Scheme
参考文献
Sato, Seiichi; Futaki, Fumie; Yasuda, Reiko; Eto, Sachise; Suzuki, Yumiko; Tajima, Takaho; Eto, Yuzuru; Tahara, Yuki
Patent: US2012/282386 A1, 2012 ;
US 20120282386 A1
