1-苄基-4-羟基-1,8-萘啶-2(1h)-酮合成路线 （共 9 条）
反应条件
potassium tert-butylate in xylene T=150°C; 2 h;
参考文献
Otsuka Pharmaceutical Factory, Inc.
Patent: EP1426374 A1, 2004 ;
Location in patent: Page 8 ;
反应条件
potassium carbonate in methanol; water T=20°C; 3 h;
参考文献
Ban, Hitoshi; Muraoka, Masami; Ohashi, Naohito
Tetrahedron, 2005 , vol. 61, # 42 p. 10081 - 10092
反应条件
1: 71 percent / 10 h / 90 °C 2: 63 percent / acetic acid / 2 h / Heating 3: 100 percent / K2CO3; water / methanol / 3 h / 20 °C View Scheme
参考文献
Ban, Hitoshi; Muraoka, Masami; Ohashi, Naohito
Tetrahedron Letters, 2003 , vol. 44, # 32 p. 6021 - 6023
反应条件
1: 63 percent / acetic acid / 2 h / Heating 2: 100 percent / K2CO3; water / methanol / 3 h / 20 °C View Scheme
参考文献
Ban, Hitoshi; Muraoka, Masami; Ohashi, Naohito
Tetrahedron Letters, 2003 , vol. 44, # 32 p. 6021 - 6023
反应条件
1: 71 percent / 10 h / 90 °C 2: 63 percent / acetic acid / 2 h / Heating 3: 100 percent / K2CO3; water / methanol / 3 h / 20 °C View Scheme
参考文献
Ban, Hitoshi; Muraoka, Masami; Ohashi, Naohito
Tetrahedron Letters, 2003 , vol. 44, # 32 p. 6021 - 6023
反应条件
trichlorophosphate 2 h; Heating / reflux;
参考文献
WO2008/24423 A2, ;
Page/Page column 43 ;
反应条件
1: 84 percent / POCl3 / 0.5 h / 90 °C 2: 91 percent / cesium carbonate / Pd(PPh3)4 / dioxane / 4 h / Heating View Scheme
参考文献
Ban, Hitoshi; Muraoka, Masami; Ohashi, Naohito
Tetrahedron Letters, 2003 , vol. 44, # 32 p. 6021 - 6023
反应条件
trichlorophosphate
2 h; Heating / reflux;
参考文献
Yang, Zhen; Fathi, Reza; Zhu, Qiang; Cho, Hyun-Joon; Liu, Yixin; Sandrasagra, Anthony; Wobbe, C. Richard
Patent: US2009/54477 A1, 2009 ;
Location in patent: Page/Page column 18 ;
US 20090054477 A1
反应条件
trichlorophosphate
T=90°C;
参考文献
Ban, Hitoshi; Muraoka, Masami; Ohashi, Naohito
Tetrahedron, 2005 , vol. 61, # 42 p. 10081 - 10092
