2',6'-二甲基乙酰苯胺合成路线 （共 29 条）
反应条件
sulfuric acid T=80°C; 1 h;
参考文献
Hanefeld
Archiv der Pharmazie, 1981 , vol. 314, # 4 p. 315 - 328
反应条件
in chloroform 0.5 h; Ambient temperature;
参考文献
Kamijo, Tetsuhide; Yamamoto, Ryoji; Harada, Hiromu; Iizuka, Kinji
Chemical & Pharmaceutical Bulletin, 1982 , vol. 30, # 11 p. 4242 - 4244
反应条件
1: 51 percent / H2O2 / aq. acetic acid / Heating 2: 32 percent / H2SO4 / 1 h / 80 °C View Scheme
参考文献
Archiv der Pharmazie, , vol. 314, # 4 p. 315 - 328
反应条件
acetate buffer; sodium perchlorate; sodium bromide in acetonitrile T=40°C; var. conc. of NaBr, also without NaBr, other O-aroyl-N-(2,6-dimethylphenyl)hydroxylamines; var. pH; Product distributionMechanism;
参考文献
Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), , # 4 p. 663 - 672
参考文献
Chemische Berichte, , vol. 89, p. 224,234
反应条件
1: glacial acetic acid / Einleiten von nitrosen Gasen 2: benzene View Scheme
参考文献
Yager, Kraig; Chu, Shaosong; Appelt, Krzysztof; Li, Xiaoming
Patent: US2005/54697 A1, 2005 ;
Location in patent: Page/Page column 73 ;
US 20050054697 A1
反应条件
1: KMnO4 2: aqueous HCl View Scheme
参考文献
Noelting; Gachot
Chemische Berichte, 1906 , vol. 39, p. 74
反应条件
sodium hydroxide; tetra(n-butyl)ammonium hydrogensulfate; potassium carbonate 1.) toluene, 30-35 deg C, 30 min, 2.) toluene, 30-35 deg C, 1 h; Yield given. Multistep reaction;
参考文献
Kalkote; Choudhary; Natu; Lahoti; Ayyangar
Synthetic Communications, 1991 , vol. 21, # 18-19 p. 1889 - 1900
反应条件
T=20 - 25°C; 24 h; Irradiationon silica gel; Yield given;
参考文献
Magdy, M.; Malik, Abdel-; Mayo, Paul de
Canadian Journal of Chemistry, 1984 , vol. 62, p. 1275 - 1278
反应条件
1.1: nitric acid; acetic acid; sulfuric acid / 1 h / 0 - 20 °C 2.1: palladium 10 on activated carbon; hydrogen / ethanol; methanol; acetic acid / 36 h / 20 °C 3.1: sodium nitrite; sulfuric acid / water / 0.5 h / 0 °C 3.2: 2 h / 100 °C View Scheme
参考文献
FOVEA PHARMACEUTICALS; FEUTRILL, John; LERICHE, Caroline; MIDDLEMISS, David
Patent: WO2013/37705 A2, 2013 ;
WO 2013/037705 A2
