1-甲基-2,3-二氢-1H-吡咯并[3,2-c]吡啶合成路线 （共 5 条）
反应条件
triethylamine; 4-nitrophenylsulfonyl chloride in dichloromethane T=0 - 20°C; 3 h;
参考文献
Spivey; Maddaford; Leese; Redgrave
Journal of the Chemical Society. Perkin Transactions 1, 2001 , # 15 p. 1785 - 1794
反应条件
diisobutylaluminium hydride in dichloromethane 20 h; Heating;
参考文献
Tetrahedron Letters, , vol. 39, # 48 p. 8919 - 8922
反应条件
1.1: 38.6 g / CH2Cl2; H2O / 0.42 h / 20 °C 2.1: t-butyllithium / tetrahydrofuran; pentane / 3.5 h / -78 - -15 °C 2.2: 75 percent / tetrahydrofuran; pentane / 2 h / -78 - 20 °C 3.1: 100 percent / triethylamine; methanesulfonyl chloride / CH2Cl2 / 2 h / -10 - 20 °C 4.1: 11.0 g / diisobutylaluminum hydride / CH2Cl2 / 20 h / Heating View Scheme
参考文献
Spivey, Alan C.; Fekner, Tomasz; Spey, Sharon E.; Adams, Harry
Journal of Organic Chemistry, 1999 , vol. 64, # 26 p. 9430 - 9443
反应条件
1.1: t-butyllithium / tetrahydrofuran; pentane / 3.5 h / -78 - -15 °C 1.2: 75 percent / tetrahydrofuran; pentane / 2 h / -78 - 20 °C 2.1: 100 percent / triethylamine; methanesulfonyl chloride / CH2Cl2 / 2 h / -10 - 20 °C 3.1: 11.0 g / diisobutylaluminum hydride / CH2Cl2 / 20 h / Heating View Scheme
参考文献
Spivey, Alan C.; Fekner, Tomasz; Spey, Sharon E.; Adams, Harry
Journal of Organic Chemistry, 1999 , vol. 64, # 26 p. 9430 - 9443
反应条件
1: 1.75 g / CH2Cl2 / 3 h / 20 °C 2: 11.0 g / diisobutylaluminum hydride / CH2Cl2 / 20 h / Heating View Scheme
参考文献
Journal of Organic Chemistry, , vol. 64, # 26 p. 9430 - 9443
