(R)-N-苄基-2-(苄氧羰基氨基)-3-羟基丙酰胺合成路线 （共 4 条）
反应条件
silver(l) oxide in acetonitrile T=20°C;
参考文献
LeTiran, Arnaud; Stables, James P.; Kohn, Harold
Journal of Medicinal Chemistry, 2002 , vol. 45, # 21 p. 4762 - 4773
反应条件
1: in acetone 2: With sodium hydroxide in water; acetone T=0 - 5°C; Product distribution / selectivity;
参考文献
PLIVA HRVATSKA D.O.O.
Patent: US2010/240926 A1, 2010 ;
Location in patent: Page/Page column 5 ;
反应条件
1: (R)-N-benzyl 2-N-(benzyloxycarbonyl)amino-3-hydroxypropionamide With silver(l) oxide in acetonitrile 0.5 h; 2: methyl iodide in acetonitrile T=20°C; 96 h;
参考文献
PLIVA HRVATSKA D.O.O.
Patent: US2010/240926 A1, 2010 ;
Location in patent: Page/Page column 6 ;
反应条件
1: 90 percent / Ag2O / acetonitrile / 20 °C 2: 96 percent / H2 / Pd/C / methanol / 4 h / 20 °C / 760 Torr View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 45, # 21 p. 4762 - 4773
