trifluoroacetic acid in water; acetonitrile T=20°C; 3 h;

Stage #1: <a href="#" onclick="return RXDsubstances(event, this, '104581', constants.ctx, '0')">2-picoline</a> <b>With</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '1209227', constants.ctx, '0')">n-butyllithium</a>;&nbsp;<a href="#" onclick="return RXDsubstances(event, this, '605301', constants.ctx, '0')">N-ethyl-N,N-diisopropylamine</a>;&nbsp;<a href="#" onclick="return RXDsubstances(event, this, '8402623', constants.ctx, '0')">sodium t-butanolate</a>&nbsp;<b>in</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '102391', constants.ctx, '0')">tetrahydrofuran</a>;&nbsp;<a href="#" onclick="return RXDsubstances(event, this, '1730733', constants.ctx, '0')">hexane</a> <br />T=-78&deg;C;&nbsp;0.25&nbsp;h;&nbsp;<br />Stage #2: <a href="#" onclick="return RXDsubstances(event, this, '1730824', constants.ctx, '0')">dimethyl-disulfide</a> &nbsp;<b>in</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '102391', constants.ctx, '0')">tetrahydrofuran</a>;&nbsp;<a href="#" onclick="return RXDsubstances(event, this, '1730733', constants.ctx, '0')">hexane</a> <br />T=-78&deg;C;&nbsp;0.25&nbsp;h;&nbsp;&nbsp;Further stages.;&nbsp;<br /> &nbsp;

<b>Multi-step reaction with 2 steps<br /> </b>1: 1.) NHCO₃; 2.) S₈, Et₃N / 1.) CH₂Cl₂, H₂O; 2.) DMF, 25-30 deg C, 6.5 h; 3.) DMF, r.t., 20 min<br />2: 2.) 35 percent aq. HCl / 1.) THF, ether, -78 deg C, 30 min; 2.) ether, THF, ethanol, -78 deg C, 15 min<br /> <br /> &nbsp;

<b>With</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '1098214', constants.ctx, '0')">hydrogenchloride</a> <br />&nbsp;1.) THF, ether, -78 deg C, 30 min; 2.) ether, THF, ethanol, -78 deg C, 15 min;&nbsp;&nbsp;Yield givenMultistep reaction;&nbsp;<br /> &nbsp;