4-乙基-3,5-二甲基-1H-吡咯-2-甲酸乙酯合成路线 （共 41 条）
反应条件
1.1: 100 percent / NaOH / ethane-1,2-diol / 1 h / Heating
2.1: 75 percent / PhCOCl / 0 - 20 °C
3.1: 162 mg / HBr; AcOH / methanol / 0.5 h / 20 °C
4.1: CuCl2 / dimethylformamide / 4 h / 20 °C
4.2: 31 percent / H2SO4; CF3CO2H / 0.75 h / 20 °C
View Scheme
参考文献
Lash, Timothy D.; Chen, Shaohua
Tetrahedron, 2005 , vol. 61, # 49 p. 11577 - 11600
反应条件
ammonium cerium (IV) nitrate
参考文献
Ward, Patrick; Chandler, Rebecca R.; Huggins, Michael T.
Supramolecular Chemistry, 2013 , vol. 25, # 5 p. 286 - 291
反应条件
sulfuryl dichloride; water
1.) Et2O, r.t., 24 h, 2.) acetone, reflux, 45 min; Multistep reaction. Yields of byproduct given;
参考文献
Boudif, Arezki; Momenteau, Michel
Journal of the Chemical Society. Perkin Transactions 2, 1996 , vol. 1996, # 11 p. 1235 - 1242
反应条件
diethyl ether; bromine
参考文献
Huggins, Michael T.; Tipton, Adrianne K.; Chen, Qingqi; Lightner, David A.
Monatshefte fur Chemie, 2000 , vol. 131, # 8 p. 825 - 838
反应条件
bromine in tetrachloromethane
Ambient temperaturevar. molar ratio Br2:pyrrole; MechanismKineticsProduct distribution;
参考文献
Angelini, Giancarlo; Giancaspro, Carlo; Illuminati, Gabriello; Sleiter, Giancarlo
Journal of Organic Chemistry, 1980 , vol. 45, # 10 p. 1786 - 1790
反应条件
1: 100 percent / NaOH / ethane-1,2-diol / 1 h / Heating
2: 75 percent / PhCOCl / 0 - 20 °C
View Scheme
参考文献
Wijesekera, Tilak P.; Paine, John B.; Dolphin, David
Journal of Organic Chemistry, 1985 , vol. 50, # 20 p. 3832 - 3838
反应条件
sodium hydroxide; benzoyl chloride
1.) ethylene glycol, reflux 45 min, 2.) toluene, -5-0 deg C, 1 h; Yield givenMultistep reaction;
参考文献
Lash, Timothy D.; Mani, Ukti N.; Drinan, Martin A.; Zhen, Chun; Hall, Troii; Jones, Marjorie A.
Journal of Organic Chemistry, 1999 , vol. 64, # 2 p. 464 - 477
反应条件
1.1: sulfuryl chloride / CH2Cl2 / 1.5 h / 20 °C
1.2: 92 percent / water / acetone / 2 h / Heating
2.1: 94 percent / NaHCO3; I2 / H2O; 1,2-dichloro-ethane / 0.75 h / Heating
3.1: 98 percent / H2 / PtO2 / methanol
4.1: 87 percent / phenylmethanol / 48 h / 85 °C
View Scheme
参考文献
Wijesekera, Tilak P.; Paine, John B.; Dolphin, David
Journal of Organic Chemistry, 1985 , vol. 50, # 20 p. 3832 - 3838
反应条件
1: With sulfuryl dichloride in dichloromethane
T=20°C; 1.5 h;
2: With water in acetone
2 h; Heating;
参考文献
Gould, Stephanie L.; Kodis, Gerdenis; Liddell, Paul A.; Palacios, Rodrigo E.; Brune, Alicia; Gust, Devens; Moore, Thomas A.; Moore, Ana L.
Tetrahedron, 2006 , vol. 62, # 9 p. 2074 - 2096
反应条件
sulfuryl dichloride; water
1.) Et2O, r.t., 24 h, 2.) acetone, reflux, 45 min; Multistep reaction. Yields of byproduct given;
参考文献
Boudif, Arezki; Momenteau, Michel
Journal of the Chemical Society. Perkin Transactions 2, 1996 , vol. 1996, # 11 p. 1235 - 1242
