1: 76 percent / Et3N, H2 / Pd/C / ethyl acetate / 24 h / 50 °C / 760 Torr 2: 79 percent / DBU / CH2Cl2 / 3 h / Ambient temperature 3: 1.) BF3*OEt2, 4A MS, 2.) 2,6-lutidine / 1.) CH2Cl2, -60 deg C, 30 min, 2.) CH2Cl2, -20 deg C, 1 h 4: 50 percent / H2, Et3N / Pd/C / ethyl acetate; ethanol / 72 h / 50 °C / 38000 Torr 5: 65 percent / DBU / CH2Cl2 / 6 h / Ambient temperature 6: 69 percent / 4A MS, TMSOTf / CH2Cl2 / 0.33 h / -20 °C 7: 79 percent / Pd(MeCN)2Cl2 / acetone; H2O / Ambient temperature View Scheme

<b>Multi-step reaction with 3 steps<br /> </b>1: 31 percent / HCl gas / Ambient temperature<br />2: 65 percent / pyridine / -35 - 20 &deg;C<br />3: 93 percent / imidazole, DMAP / dimethylformamide / 1 h<br /> <br /> &nbsp;

<b>With</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '103853', constants.ctx, '0')">1H-imidazole</a>;&nbsp;<a href="#" onclick="return RXDsubstances(event, this, '110354', constants.ctx, '0')">dmap</a>&nbsp;<b>in</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '605365', constants.ctx, '0')">N,N-dimethyl-formamide</a> <br />1&nbsp;h;&nbsp;<br /> &nbsp;

<b>Multi-step reaction with 3 steps<br /> </b>1: 31 percent / HCl gas / Ambient temperature<br />2: 65 percent / pyridine / -35 - 20 &deg;C<br />3: 93 percent / imidazole, DMAP / dimethylformamide / 1 h<br /> <br /> &nbsp;

<b>Multi-step reaction with 3 steps<br /> </b>1: hydrogenchloride / 24 h / 50 &deg;C<br />2: pyridine / 48 h / -15 &deg;C<br />3: dmap; pyridine<br /> <br /> &nbsp;