1.1: 91 percent / aq. CAN / acetonitrile / 1 h / 20 °C 2.1: aq. HCl / Heating 2.2: aq. HCl / 2 h / Heating 3.1: 151 mg / aq. HCl / 0.5 h / Heating View Scheme

1.1: 91 percent / aq. CAN / acetonitrile / 1 h / 20 °C 2.1: aq. HCl / Heating 2.2: aq. HCl / 2 h / Heating View Scheme

Stage #1: <a href="#" onclick="return RXDsubstances(event, this, '3536470', constants.ctx, '0')">cyclohexylMgCl</a> &nbsp;<b>in</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '102391', constants.ctx, '0')">tetrahydrofuran</a>;&nbsp;<a href="#" onclick="return RXDsubstances(event, this, '1696894', constants.ctx, '0')">diethyl ether</a> <br />T=-78 - -20&deg;C;&nbsp;<br />Stage #2: <a href="#" onclick="return RXDsubstances(event, this, '8084411', constants.ctx, '0')">(S)-N,N'-bis(p-methoxybenzyl)-3-methylene-6-isopropylpiperazine-2,5-dione</a> <b>With</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '2349612', constants.ctx, '0')">boron trifluoride diethyl etherate</a>&nbsp;<b>in</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '102391', constants.ctx, '0')">tetrahydrofuran</a>;&nbsp;<a href="#" onclick="return RXDsubstances(event, this, '1696894', constants.ctx, '0')">diethyl ether</a> <br />T=-78 - 20&deg;C;&nbsp;&nbsp;Further stages.;&nbsp;<br /> &nbsp;

<b>Multi-step reaction with 2 steps<br /> </b>1.1: n-BuLi / tetrahydrofuran; hexane / 0.25 h / -78 &deg;C<br />1.2: 91 percent / tetrahydrofuran; hexane / 1 h / 70 &deg;C<br />2.1: CuCN / tetrahydrofuran; diethyl ether / -78 - -20 &deg;C<br />2.2: 92 percent / BF₃*OEt₂ / tetrahydrofuran; diethyl ether / -78 - 20 &deg;C<br /> <br /> &nbsp;

<b>With</b>&nbsp; 1.) CuCN<br />&nbsp;2.) THF, -78 deg C;&nbsp;&nbsp;Yield given. Multistep reaction;&nbsp;<br /> &nbsp;