2,6-dimethylpyridine; trimethylsilyl trifluoromethanesulfonate in dichloromethane - 78 deg C, 30 min, RT, 1 h;

<b>With</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '11343357', constants.ctx, '0')">sodium periodate</a>&nbsp;<b>in</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '102391', constants.ctx, '0')">tetrahydrofuran</a>;&nbsp;<a href="#" onclick="return RXDsubstances(event, this, '3587155', constants.ctx, '0')">water</a> <br /> <br /> &nbsp;

<b>Multi-step reaction with 4 steps<br /> </b>1: 97 percent / DEAD, PPh₃ / tetrahydrofuran / 0 &deg;C<br />2: 95 percent / NaOH / methanol; H₂O<br />3: 65 percent / BnNEt₃Br, NaOH / CH₂Cl₂; H₂O / 0.17 h / 25 &deg;C<br />4: 87 percent / NaIO₄ / tetrahydrofuran; H₂O<br /> <br /> &nbsp;

<b>Multi-step reaction with 3 steps<br /> </b>1: 95 percent / NaOH / methanol; H₂O<br />2: 65 percent / BnNEt₃Br, NaOH / CH₂Cl₂; H₂O / 0.17 h / 25 &deg;C<br />3: 87 percent / NaIO₄ / tetrahydrofuran; H₂O<br /> <br /> &nbsp;