3-(2-吗啉-4-基-乙氧基)-苯甲酸合成路线 （共 4 条）
反应条件
1: With methanol; sodium hydroxide; water 18 h; Heating / reflux; 2: With hydrogenchloride in water pH=2;
参考文献
Bartkovitz, David Joseph; Chen, Yi; Chu, Xin-Jie; Luk, Kin-Chun; Rossman, Pamela Loreen; So, Sung-Sau
Patent: US2007/60607 A1, 2007 ;
Location in patent: Page/Page column 60 ;
US 20070060607 A1
反应条件
hydrogenchloride; water T=100°C; 2.5 h;
参考文献
WO2012/80735 A1, ;
Page/Page column 47; 48 ;
WO 2012/080735 A1
反应条件
1: potassium carbonate / acetonitrile / 60 °C / Inert atmosphere 2: potassium carbonate / acetonitrile / 25 - 60 °C / Inert atmosphere 3: hydrogenchloride; water / 2.5 h / 100 °C View Scheme
参考文献
WO2012/80735 A1, ;
WO 2012/080735 A1
反应条件
1: sulfuric acid / 85 °C / Inert atmosphere 2: potassium carbonate / acetonitrile / 60 °C / Inert atmosphere 3: potassium carbonate / acetonitrile / 25 - 60 °C / Inert atmosphere 4: hydrogenchloride; water / 2.5 h / 100 °C View Scheme
参考文献
WO2012/80735 A1, ;
WO 2012/080735 A1
