1: With n-butyllithium; (S)-TRIOZ; (R)-(-)-4-phenyl-2-oxazolidinone in tetrahydrofuran T=-78°C; 2: With lithium hydroxide; water; dihydrogen peroxide in tetrahydrofuran optical yield given as percent ee;

1.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -78 °C / Inert atmosphere 1.2: 2 h / -78 °C / Inert atmosphere 2.1: lithium hydroxide hydrate; dihydrogen peroxide / tetrahydrofuran; water / 12 h / 20 °C / Inert atmosphere 2.2: pH 3 / Inert atmosphere View Scheme

1: With n-butyllithium; (S)-TRIOZ; (R)-(-)-4-phenyl-2-oxazolidinone in tetrahydrofuran T=-78°C; 2: With lithium hydroxide; water; dihydrogen peroxide in tetrahydrofuran optical yield given as percent ee;