4-氯吡啶-2-羧酸叔丁酯合成路线 （共 9 条）
反应条件
pyridine in 1,2-dichloro-ethane T=-40 - 50°C; 24 h;
参考文献
Borzilleri, Robert M.; Kim, Kyoung S.; Cai, Zhen-Wei
Patent: US2005/239820 A1, 2005 ;
Location in patent: Page/Page column 17 ;
US 20050239820 A1
反应条件
1: tert-butyl alcohol With n-butyllithium in tetrahydrofuran; hexane T=0 - 20°C; 2: 4-chloro-pyridine-2-carboxylic acid methyl ester in tetrahydrofuran; hexane T=20°C;
参考文献
KinaGen, Inc.
Patent: US2009/12091 A1, 2009 ;
Location in patent: Page/Page column 46-47 ;
US 20090012091 A1
反应条件
in tetrahydrofuran 3 - 4 h;
参考文献
US2004/122237 A1, ;
Page 88 ;
US 20040122237 A1
参考文献
WO2010/66684 A2, ;
Page/Page column 98 ;
WO 2010/066684 A2
反应条件
1: thionyl chloride; sodium bromide / 20 °C / Inert atmosphere; Reflux 2: pyridine / 1,2-dichloro-ethane / 0 - 50 °C / Inert atmosphere View Scheme
参考文献
WO2012/112570 A1, ;
WO 2012/112570 A1
反应条件
1: thionyl chloride; N,N-dimethyl-formamide / 2 h / |Reflux 2: pyridine / dichloromethane / 16 h / -40 - 50 °C View Scheme
反应条件
1.1: potassium tert-butylate / N,N-dimethyl-formamide / 0.5 h / 20 °C 1.2: 2 h / 80 °C 2.1: dichloromethane / 16 h / 20 °C 3.1: trifluoroacetic acid; triethylsilane / dichloromethane / 16 h / 50 °C 4.1: HATU; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 16 h / 20 °C View Scheme
反应条件
1: With sodium azide in dimethyl sulfoxide
T=130°C; 15 h;
2: With triphenylphosphine in tetrahydrofuran; water
T=70°C;
参考文献
Borzilleri, Robert M.; Kim, Kyoung S.; Cai, Zhen-Wei
Patent: US2005/239820 A1, 2005 ;
Location in patent: Page/Page column 17 ;
US 20050239820 A1
反应条件
1.1: potassium tert-butylate / N,N-dimethyl-formamide / 0.5 h / 20 °C
1.2: 2 h / 80 °C
2.1: dichloromethane / 16 h / 20 °C
3.1: trifluoroacetic acid; triethylsilane / dichloromethane / 16 h / 50 °C
4.1: sulfuric acid / water / 3 h / |Reflux
View Scheme
参考文献
SUZHOU ZELGEN BIOPHARMACEUTICAL CO., LTD.; Feng, Weidong; Gao, Xiaoyong; Dai, Xiaojun
Patent: US2013/35492 A1, 2013 ;
